4-[(Aminoalkyl)amino]-1,2-dimethoxynaphthalenes as antimalarial agents

4-[(Aminoalkyl)amino]-1,2-dimethoxynaphthalenes as antimalarial agents

A series of 4-[N-(aminoalkyl)amino]-1,2-dimethoxynaphthalenes was prepared and tested for radical curative activity in rhesus monkeys infected with P. cynomolgi. Some radical curative activity was observed.

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Bibliographische Detailangaben
Veröffentlicht in:Journal of medicinal chemistry 1980-05, Vol.23 (5), p.516-519
Hauptverfasser: Archer, Sydney, Osei-Gyimah, Peter, Silbering, Stephen
Format: Artikel
Sprache:eng
Schlagworte:
Animals
Antimalarials - chemical synthesis
Chemical Phenomena
Chemistry
Haplorhini
Macaca mulatta
Malaria - drug therapy
Naphthalenes - chemical synthesis
Naphthalenes - pharmacology
Plasmodium - drug effects
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Zusammenfassung:A series of 4-[N-(aminoalkyl)amino]-1,2-dimethoxynaphthalenes was prepared and tested for radical curative activity in rhesus monkeys infected with P. cynomolgi. Some radical curative activity was observed.
ISSN:0022-2623
1520-4804
DOI:10.1021/jm00179a009