STUDIES ON THE IONOPHOROUS ANTIBIOTICS. XXIV: LEUSERAMYCIN, A NEW POLYETHER ANTIBIOTIC PRODUCED BY STREPTOMYCES HYGROSCOPICUS

STUDIES ON THE IONOPHOROUS ANTIBIOTICS. XXIV: LEUSERAMYCIN, A NEW POLYETHER ANTIBIOTIC PRODUCED BY STREPTOMYCES HYGROSCOPICUS

A new antibiotic leuseramycin has been isolated from the cultured mycelium of the strain of Streptomyces hygroscopicus TM-531. Physicochemical data, in particular those of 1H- and 13C-NMR spectra, revealed that leuseramycin is closely related to dianemycin in its structure, the former having a methy...

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Veröffentlicht in:Journal of antibiotics 1980, Vol.33(2), pp.137-143
Hauptverfasser: MIZUTANI, TAKU, YAMAGISHI, MICHIO, HARA, HIROSHI, KAWASHIMA, AKIRA, OMURA, SADAFUMI, OZEKI, MASAHIRO
Format: Artikel
Sprache:eng
Schlagworte:
Anti-Bacterial Agents - analysis
Anti-Bacterial Agents - biosynthesis
Anti-Bacterial Agents - pharmacology
Antifungal Agents
Bacteria - drug effects
Chemical Phenomena
Chemistry, Physical
Ethers - analysis
Ethers - biosynthesis
Ethers - pharmacology
Ionophores - analysis
Ionophores - biosynthesis
Ionophores - pharmacology
Streptomyces - growth & development
Streptomyces - metabolism
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Zusammenfassung:A new antibiotic leuseramycin has been isolated from the cultured mycelium of the strain of Streptomyces hygroscopicus TM-531. Physicochemical data, in particular those of 1H- and 13C-NMR spectra, revealed that leuseramycin is closely related to dianemycin in its structure, the former having a methyl group in place of the hydroxymethyl group at C-30. It is active against Gram-positive bacteria, some phytopathogenic fungi and some protozoa.
ISSN:0021-8820
1881-1469
DOI:10.7164/antibiotics.33.137