Serum uric acid: Correlation with biochemical, anthropometric, clinical and behavioral parameters in 10,000 israeli men

Serum uric acid (SUA) was measured in a group of 10,000 middle-aged male civil servants and municipal employees in Israel ( x ̄ = 4.77 mg%, S.D. = 0.96 mg% ). SUA levels did not vary appreciably by age or country of birth. There were small significant correlations between SUA and weight [absolute (0.28) and relative (0.30)], triceps and subscapular skinfolds (0.13 and 0.23), systolic blood pressure (SBP) (0.10), diastolic blood pressure (DBF) (0.20) and serum cholesterol (0.13). SUA was elevated in men with coronary heart disease (CHD) and rose with increased level of education. It was negatively correlated with high-density lipoprotein (HDL) cholesterol (− 0.10) and total fat intake (− 0.10), and was significantly reduced among cigarette smokers and in men with diabetes mellitus or peptic ulcer. Multiple regression analysis revealed that 11 variables were significantly related to SUA, together accounting for about 16% of SUA variance (multiple r = 0.40). The Quetelet index [ weight (W) height (H) 2 ] (QI) made most of the contribution. Among the other variables, only blood pressure and the presence of diabetes mellitus accounted for more than 1 % of the variance.