Inhibition of Gastric Secretion of Hydrochloric Acid in vivo by Carbonic Anhydrase Inhibition

THIS preliminary communication on the inhibition of acid secretion in vivo in dogs by one of a new group of potent carbonic anhydrase inhibitors is prompted by the recent report of Davies and Edelman 1 , which has appeared since our work was completed. These workers have shown that several other known carbonic anhydrase inhibitors, which include prontosil, p -toluenesulphonamide, p -sulphonamidobenzoate and thiophene-2-sulphonamide, can suppress the in vitro acid secretion of the isolated frog and toad gastric mucosa, although sulphanilamide was without effect.