Mitochondrial Water in Myocardial Ischemia: Investigation with Nuclear Magnetic Resonance

Nuclear magnetic resonance studies of mitochondria isolated from ischemic hearts after coronary vessel occlusion indicated a decrease in water proton relaxation times. This change coincided with a decrease in the hydration of the samples. It is suggested that in ischemia, changes in macromolecular h...

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Veröffentlicht in:	Science (American Association for the Advancement of Science) 1980-06, Vol.208 (4449), p.1267-1269
Hauptverfasser:	Michael, Lloyd H., Seitz, Patricia, McMillin-Wood, Jeanie, Chang, Donald, Hazlewood, Carlton, Entman, Mark L.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cell Fractionation - methods Centrifugation Coronary Disease - metabolism Coronary Disease - pathology Dogs Grants Ischemia Magnetic Resonance Spectroscopy Methodism Mitochondria Mitochondria, Heart - metabolism Myocardial ischemia Nuclear magnetic resonance Pediatrics Protons Relaxation time Water - metabolism
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Zusammenfassung:	Nuclear magnetic resonance studies of mitochondria isolated from ischemic hearts after coronary vessel occlusion indicated a decrease in water proton relaxation times. This change coincided with a decrease in the hydration of the samples. It is suggested that in ischemia, changes in macromolecular hydration may be one of the first mechanisms to alter function in the mitochondria, which are vital to the energy-transducing process in heart muscle.
ISSN:	0036-8075 1095-9203
DOI:	10.1126/science.6246584