Types of Disease and Models for Their Genetic Analysis

Types of Disease and Models for Their Genetic Analysis

The authors compare schizophrenia with several other diseases and discuss how a few simple models that have already been successfully applied in other cases could be used in the genetic analysis of schizophrenia and MAO activity. Among the diseases discussed are Huntington's disease, xanthomato...

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Veröffentlicht in:Schizophrenia bulletin 1980, Vol.6 (2), p.368-374
Hauptverfasser: Elston, Robert C., Namboodiri, Kadambari K.
Format: Artikel
Sprache:eng
Schlagworte:
Adolescent
Adult
Aged
Analysis
Child
Child, Preschool
Chromosome Mapping
Etiology
Genetic Markers
Genetic Models
Genetics
Genotype
Human
Humans
Huntington Disease - genetics
Infant
Middle Aged
Models, Theoretical
Monoamine Oxidase - blood
Phenotype
Schizophrenia
Schizophrenia - enzymology
Schizophrenia - genetics
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Beschreibung
Zusammenfassung:The authors compare schizophrenia with several other diseases and discuss how a few simple models that have already been successfully applied in other cases could be used in the genetic analysis of schizophrenia and MAO activity. Among the diseases discussed are Huntington's disease, xanthomatosis, and diabetes. The authors recommend undertaking multivariate studies of monoamine oxidase, dopamine β-hydroxylase, and other traits associated with schizophrenia in single, large pedigrees ascertained through schizophrenic probands.
ISSN:0586-7614
1745-1701
DOI:10.1093/schbul/6.2.368