Effect of Particle Size on Ophthalmic Bioavailability of Dexamethasone Suspensions in Rabbits

Three suspensions of 0.1% [3H]dexamethasone were prepared with mean particle sizes of 5.75, 11.5, and 22.0 μm. The suspensions were dosed topically to the right eyes of rabbits. Their bioavailability was compared by measuring aqueous humor and corneal levels over 5hr. A statistically significant ran...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Journal of pharmaceutical sciences 1980-04, Vol.69 (4), p.391-394
Hauptverfasser:	Schoenwald, R.D., Stewart, P.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Aqueous Humor - metabolism bioavailability Bioavailability-dexamethasone Bioavailability—dexamethasone, ophthalmic suspensions, effect of particle size, rabbits Biological Availability Cornea - metabolism Dexamethasone - metabolism Dexamethasone-ophthalmic suspensions Dexamethasone—ophthalmic suspensions, bioavailability, effect of particle size, rabbits effect of particle size Eye - metabolism Ophthalmic preparations-dexamethasone suspensions Ophthalmic preparations—dexamethasone suspensions, bioavailability, effect of particle size, rabbits Ophthalmic Solutions ophthalmic suspensions Particle Size Rabbits Suspensions
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	Three suspensions of 0.1% [3H]dexamethasone were prepared with mean particle sizes of 5.75, 11.5, and 22.0 μm. The suspensions were dosed topically to the right eyes of rabbits. Their bioavailability was compared by measuring aqueous humor and corneal levels over 5hr. A statistically significant rank-order correlation was observed between increasing drug levels and decreasing particle size.
ISSN:	0022-3549 1520-6017
DOI:	10.1002/jps.2600690407