Cholestyramine Promotes Receptor-Mediated Low-Density-Lipoprotein Catabolism

We studied the influence of cholestyramine (24 g per day) on receptor-mediated and receptor-independent low-density-lipoprotein catabolism in five women with heterozygous familial hypercholesterolemia. Cholestyramine lowered the level of circulating low-density-lipoprotein apoprotein by doubling (P

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Bibliographische Detailangaben
Veröffentlicht in:	The New England journal of medicine 1980-05, Vol.302 (22), p.1219-1222
Hauptverfasser:	Shepherd, James, Packard, Christopher J, Bicker, Susan, Lawrie, T. D. Veitch, Morgan, H. Gemmell
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Atherosclerosis Biochemistry Cholesterol Cholesterol - blood Cholestyramine Resin - administration & dosage Cholestyramine Resin - pharmacology Cholestyramine Resin - therapeutic use Heterozygote Heterozygotes Humans Hypercholesterolemia Hyperlipoproteinemia Type II - blood Hyperlipoproteinemia Type II - drug therapy Hyperlipoproteinemia Type II - metabolism Iodine Lipids Lipoprotein receptors Lipoproteins, LDL - blood Lipoproteins, LDL - metabolism Low density lipoprotein Metabolism Middle Aged Receptor density Receptors, Drug - metabolism
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Beschreibung
Zusammenfassung:	We studied the influence of cholestyramine (24 g per day) on receptor-mediated and receptor-independent low-density-lipoprotein catabolism in five women with heterozygous familial hypercholesterolemia. Cholestyramine lowered the level of circulating low-density-lipoprotein apoprotein by doubling (P
ISSN:	0028-4793 1533-4406
DOI:	10.1056/NEJM198005293022202