Prolongation of Effects of Adrenal Cortical Secretion by Ascorbic Acid: Proposed Mechanism of Action.

Summary The influence of ascorbic acid treatment on the hematologic effects of cortisone and of ACTH was investigated. The vitamin (plus hormones) prolongs these effects beyond that in animals which receive saline + hormones. These data suggest that the circulating titer of cortical hormone is maint...

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Veröffentlicht in:	Experimental biology and medicine (Maywood, N.J.) N.J.), 1952-05, Vol.80 (1), p.88-91
Hauptverfasser:	Bacchus, Habeeb, Altszuler, Norman, Heiffer, Melvin H.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adrenal Cortex - physiology Ascorbic Acid - pharmacology Humans Old Medline Vitamins
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Zusammenfassung:	Summary The influence of ascorbic acid treatment on the hematologic effects of cortisone and of ACTH was investigated. The vitamin (plus hormones) prolongs these effects beyond that in animals which receive saline + hormones. These data suggest that the circulating titer of cortical hormone is maintained for long periods by vitamin treatment. This observation is discussed in relation to previous findings, and a mechanism proposed for the relationship of ascorbic acid to pituitary-adrenal activity.
ISSN:	0037-9727 1535-3702 1535-3699
DOI:	10.3181/00379727-80-19533