The effect of age on the intravenous sodium glycocholate test

The effect of age on the intravenous sodium glycocholate test

The clearance of an injected dose of sodium glycocholate has been studied in a group of 23 control subjects who had no evidence of liver disease. A significant correlation was found between bile salt clearance and age. No significant difference was found between the bile salt clearance of male and f...

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Veröffentlicht in:Clinica chimica acta 1980-01, Vol.100 (3), p.193-200
Hauptverfasser: Beckett, Geoffrey J., Douglas, J.Graham, Nimmo, Ian A., Finlayson, Niall D.C., Percy-Robb, Iain W.
Format: Artikel
Sprache:eng
Schlagworte:
Adolescent
Adult
Age Factors
Aged
Albumins - pharmacology
Female
Glycocholic Acid - blood
Glycocholic Acid - metabolism
Hemolysis
Humans
Kinetics
Liver Function Tests
Male
Middle Aged
Models, Biological
Time Factors
Veins
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Zusammenfassung:The clearance of an injected dose of sodium glycocholate has been studied in a group of 23 control subjects who had no evidence of liver disease. A significant correlation was found between bile salt clearance and age. No significant difference was found between the bile salt clearance of male and female subjects. Data derived from a simple compartmental model indicated that decreased clearance of bile salt with age was not specifically related to degenerative changes in hepatocellular integrity, hepatic uptake of bile salts or bile flow.
ISSN:0009-8981
1873-3492
DOI:10.1016/0009-8981(80)90266-1