Identification of Collagenase in Cultured Blood Mononuclear Cells

Identification of Collagenase in Cultured Blood Mononuclear Cells

Mononuclear cells isolated from peripheral whole blood were fractionated by erythrocyte-rosetting into T cells and non-T cell subpopulations which were tested for collagenase-producing capacity. Mononuclear cells and purified T lymphocytes, as well as non-T (B) lymphocytes, produced collagenase duri...

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Veröffentlicht in:Journal of dental research 1980-01, Vol.59 (1), p.2-10
Hauptverfasser: Simpson, John W., Mackler, B.F., O'Neill, Peggy, Mailman, M.L.
Format: Artikel
Sprache:eng
Schlagworte:
B-Lymphocytes - enzymology
Cells, Cultured
Dentistry
Humans
Lymphocytes - enzymology
Macrophages - enzymology
Microbial Collagenase - blood
Microbial Collagenase - metabolism
Monocytes - enzymology
Peptide Hydrolases - metabolism
T-Lymphocytes - enzymology
Viscosity
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Zusammenfassung:Mononuclear cells isolated from peripheral whole blood were fractionated by erythrocyte-rosetting into T cells and non-T cell subpopulations which were tested for collagenase-producing capacity. Mononuclear cells and purified T lymphocytes, as well as non-T (B) lymphocytes, produced collagenase during serum-free culture. Removal of the macrophages from the non-T cells did not affect collagenase production by lymphocytes.
ISSN:0022-0345
1544-0591
DOI:10.1177/00220345800590010301