Gastric granuloma with eosinophilic infiltration

1. 1. A case of gastric submucosal granuloma with eosinophilic infiltration is reported as the ninth case in the literature. It is characterized by a history, clinical findings and a gross lesion suggestive of a gastric malignancy. The microscopic appearance is that of submucosal fibroblastic collagenous tissue with an evenly distributed infiltration of eosinophilic leukocytes and collections of lymphocytes. 2. 2. Although an allergic reaction is suspected, the etiologic nature of the lesion is undetermined. 3. 3. This lesion does not appear to be related to the eosinophilic granuloma of bone or soft tissues either locally or microscopically. 4. 4. We believe this lesion is more common than reported to be and that by calling attention to it we may stimulate a search for the causative agent and a method of diagnosis in future cases reported.