Dephosphorylation and activation of Acetyl-CoA carboxylase by phosphorylase phosphatase

Dephosphorylation and activation of Acetyl-CoA carboxylase by phosphorylase phosphatase

Acetyl-CoA carboxylase from rat epididymal fat tissue is activated by phosphorylase phosphatase, a reaction which is inhibited by phosphatase inhibitor-1. This activation is accompanied by a corresponding loss of 32P from the labelled enzyme. These results establish that dephosphorylation of the enz...

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Veröffentlicht in:Biochemical and biophysical research communications 1980-01, Vol.92 (2), p.389-395
Hauptverfasser: Krakower, Glenn R., Kim, Ki-Han
Format: Artikel
Sprache:eng
Schlagworte:
Acetyl-CoA Carboxylase - metabolism
Adipose Tissue - enzymology
Animals
Enzyme Activation
Kinetics
Ligases - metabolism
Liver - enzymology
Male
Phosphoprotein Phosphatases - metabolism
Phosphorylase Phosphatase - metabolism
Rats
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Zusammenfassung:Acetyl-CoA carboxylase from rat epididymal fat tissue is activated by phosphorylase phosphatase, a reaction which is inhibited by phosphatase inhibitor-1. This activation is accompanied by a corresponding loss of 32P from the labelled enzyme. These results establish that dephosphorylation of the enzyme causes its activation.
ISSN:0006-291X
1090-2104
DOI:10.1016/0006-291X(80)90345-9