Sequence of the human insulin gene

Sequence of the human insulin gene

The human insulin gene contains two intervening sequences, one is within the region transcribed into the 5′-untranslated segment of the mRNA and the other interrupts the C-peptide encoding region. A comparison of the human with the rat insulin genes indicates potential regulatory regions in the DNA...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Nature (London) 1980-03, Vol.284 (5751), p.26-32
Hauptverfasser: Bell, Graeme I, Pictet, Raymond L, Rutter, William J, Cordell, Barbara, Tischer, Edmund, Goodman, Howard M
Format: Artikel
Sprache:eng
Schlagworte:
Alleles
Animals
Base Sequence
Codon
DNA Restriction Enzymes
Genes
Genetic Variation
Humanities and Social Sciences
Humans
Insulin - genetics
multidisciplinary
Operon
Rats - genetics
RNA, Messenger - genetics
Science
Science (multidisciplinary)
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
Beschreibung
Zusammenfassung:The human insulin gene contains two intervening sequences, one is within the region transcribed into the 5′-untranslated segment of the mRNA and the other interrupts the C-peptide encoding region. A comparison of the human with the rat insulin genes indicates potential regulatory regions in the DNA segment preceding the gene and suggests that the ancestral form of the insulin gene had two intervening sequences.
ISSN:0028-0836
1476-4687
DOI:10.1038/284026a0