Secondary Products of Itanoxone

Itanoxone synthesis by Friedel-Crafts reaction between itaconic anhydride and 2-chlorobiphenyl was studied. Five isomers corresponding to possible impurities were prepared and studied to perfect a reliable and practical method to detect these impurities in itanoxone.

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Bibliographische Detailangaben
Veröffentlicht in:	Journal of pharmaceutical sciences 1980-01, Vol.69 (1), p.49-53
Hauptverfasser:	Rieu, Jean-Pierre, Mouzin, Gilbert, Cousse, Henri, Boucherle, Andre
Format:	Artikel
Sprache:	eng
Schlagworte:	Biphenyl Compounds - chemical synthesis Biphenyl Compounds - isolation & purification Butyrophenones - chemical synthesis Butyrophenones - isolation & purification Chromatography, Thin Layer Hydrogenation Hypolipidemic Agents - chemical synthesis Hypolipidemic Agents - isolation & purification Hypolipidemic agents-itanoxone Hypolipidemic agents—itanoxone, synthesis, synthesis and detection of impurities Hypouricemic agents-itanoxone Hypouricemic agents—itanoxone, synthesis, synthesis and detection of impurities Isomerism Itanoxone-synthesis Itanoxone—synthesis, synthesis and detection of impurities synthesis synthesis and detection of impurities
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Beschreibung
Zusammenfassung:	Itanoxone synthesis by Friedel-Crafts reaction between itaconic anhydride and 2-chlorobiphenyl was studied. Five isomers corresponding to possible impurities were prepared and studied to perfect a reliable and practical method to detect these impurities in itanoxone.
ISSN:	0022-3549 1520-6017
DOI:	10.1002/jps.2600690114