Further Studies on Relationship Between Human Serum Cholinesterase and Serum Albumin

Conclusion The previously observed (1,2) correlation of serum albumin and serum cholinesterase values is prlobably due to the simultaneous production of these two proteins by related synthesizing mechanisms in the liver. Albumin does not act as a precursor of serum cholinesterase. Changes in the level of this enzyme reflect the changing ability of the liver to produce both serum cholinesterase and serum albumin. It is suggested that serum cholinesterase determinations are of prognostic value in liver disease and that cholinesterase determinations may be used as an indication of albumin synthesis, particularly in the presence of administered albumin.