Potentiating Effect of Ascorbic Acid on Cortisone-Induced Gluconeogenesis

Summary The action of ascorbic acid treatment on the gluconeogenic action of cortisone was investigated in adrenalectomized mice. The deposition of glycogen in the liver is enhanced in animals treated with ascorbic acid in addition to cortisone. This observation is discussed in relation to the action of the vitamin in preventing the activation of the pituitary-adrenal axis in animals exposed to stressors. It is suggested that the vitamin may be synergistic with cortisone in some of its actions.