Phenylfurans IV: Spasmolytic 3-diethylamino-2,2-(dimethyl)propyl esters of 5-substituted Phenyl-2-furancarboxylic Acids
A series of 3-diethylamino-2,2-(dimethyl)propyl 5-substituted phenyl-2-furancarboxylates was prepared and found to be pharmacologically active in vitro as GI tract nonanticholinergic smooth muscle spasmolytic agents. One of the more active compounds in the series contained the 5-(4-nitrophenyl) grou...
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| Veröffentlicht in: | Journal of pharmaceutical sciences 1980-01, Vol.69 (1), p.107-110 |
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| container_end_page | 110 |
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| container_issue | 1 |
| container_start_page | 107 |
| container_title | Journal of pharmaceutical sciences |
| container_volume | 69 |
| creator | Burch, Homer A. White, Ronald E. Wright, George C. Goldenberg, Marvin M. |
| description | A series of 3-diethylamino-2,2-(dimethyl)propyl 5-substituted phenyl-2-furancarboxylates was prepared and found to be pharmacologically active in vitro as GI tract nonanticholinergic smooth muscle spasmolytic agents. One of the more active compounds in the series contained the 5-(4-nitrophenyl) group. |
| doi_str_mv | 10.1002/jps.2600690135 |
| format | Article |
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One of the more active compounds in the series contained the 5-(4-nitrophenyl) group.</description><identifier>ISSN: 0022-3549</identifier><identifier>EISSN: 1520-6017</identifier><identifier>DOI: 10.1002/jps.2600690135</identifier><identifier>PMID: 7354421</identifier><language>eng</language><publisher>Washington: Elsevier Inc</publisher><subject>2- (dimethyl)propyl esters of 5-substituted phenyl-2-furancarboxylic acids ; Animals ; Chemical Phenomena ; Chemistry ; Furans - chemical synthesis ; Ileum - drug effects ; Parasympatholytics - chemical synthesis ; Parasympatholytics - pharmacology ; Phenylfurans-3-diethylamino -2 ; Phenylfurans—3-diethylamino -2,2- (dimethyl)propyl esters of 5-substituted phenyl-2-furancarboxylic acids, synthesis, potential use as spasmolytic agents ; potential use as spasmolytic agents ; Rabbits ; Spasmolytic agents-3-diethylamino-2 ; Spasmolytic agents—3-diethylamino-2,2-(dimethyl)propyl esters of 5-substituted phenyl-2-furancarboxylic acids, synthesis and pharmacological properties ; synthesis ; synthesis and pharmacological properties</subject><ispartof>Journal of pharmaceutical sciences, 1980-01, Vol.69 (1), p.107-110</ispartof><rights>1980 Wiley-Liss, Inc., A Wiley Company</rights><rights>Copyright © 1980 Wiley‐Liss, Inc., A Wiley Company</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3425-706efcae73234256507277c42af7f42bc4a13dd6ca849d410e71e5a053a066133</citedby><cites>FETCH-LOGICAL-c3425-706efcae73234256507277c42af7f42bc4a13dd6ca849d410e71e5a053a066133</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fjps.2600690135$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fjps.2600690135$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27901,27902,45550,45551</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/7354421$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Burch, Homer A.</creatorcontrib><creatorcontrib>White, Ronald E.</creatorcontrib><creatorcontrib>Wright, George C.</creatorcontrib><creatorcontrib>Goldenberg, Marvin M.</creatorcontrib><title>Phenylfurans IV: Spasmolytic 3-diethylamino-2,2-(dimethyl)propyl esters of 5-substituted Phenyl-2-furancarboxylic Acids</title><title>Journal of pharmaceutical sciences</title><addtitle>J. Pharm. Sci</addtitle><description>A series of 3-diethylamino-2,2-(dimethyl)propyl 5-substituted phenyl-2-furancarboxylates was prepared and found to be pharmacologically active in vitro as GI tract nonanticholinergic smooth muscle spasmolytic agents. 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Pharm. Sci</addtitle><date>1980-01</date><risdate>1980</risdate><volume>69</volume><issue>1</issue><spage>107</spage><epage>110</epage><pages>107-110</pages><issn>0022-3549</issn><eissn>1520-6017</eissn><abstract>A series of 3-diethylamino-2,2-(dimethyl)propyl 5-substituted phenyl-2-furancarboxylates was prepared and found to be pharmacologically active in vitro as GI tract nonanticholinergic smooth muscle spasmolytic agents. One of the more active compounds in the series contained the 5-(4-nitrophenyl) group.</abstract><cop>Washington</cop><pub>Elsevier Inc</pub><pmid>7354421</pmid><doi>10.1002/jps.2600690135</doi><tpages>4</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0022-3549 |
| ispartof | Journal of pharmaceutical sciences, 1980-01, Vol.69 (1), p.107-110 |
| issn | 0022-3549 1520-6017 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_74982228 |
| source | MEDLINE; Wiley Online Library Journals Frontfile Complete; Alma/SFX Local Collection |
| subjects | 2- (dimethyl)propyl esters of 5-substituted phenyl-2-furancarboxylic acids Animals Chemical Phenomena Chemistry Furans - chemical synthesis Ileum - drug effects Parasympatholytics - chemical synthesis Parasympatholytics - pharmacology Phenylfurans-3-diethylamino -2 Phenylfurans—3-diethylamino -2,2- (dimethyl)propyl esters of 5-substituted phenyl-2-furancarboxylic acids, synthesis, potential use as spasmolytic agents potential use as spasmolytic agents Rabbits Spasmolytic agents-3-diethylamino-2 Spasmolytic agents—3-diethylamino-2,2-(dimethyl)propyl esters of 5-substituted phenyl-2-furancarboxylic acids, synthesis and pharmacological properties synthesis synthesis and pharmacological properties |
| title | Phenylfurans IV: Spasmolytic 3-diethylamino-2,2-(dimethyl)propyl esters of 5-substituted Phenyl-2-furancarboxylic Acids |
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