Phenylfurans IV: Spasmolytic 3-diethylamino-2,2-(dimethyl)propyl esters of 5-substituted Phenyl-2-furancarboxylic Acids

A series of 3-diethylamino-2,2-(dimethyl)propyl 5-substituted phenyl-2-furancarboxylates was prepared and found to be pharmacologically active in vitro as GI tract nonanticholinergic smooth muscle spasmolytic agents. One of the more active compounds in the series contained the 5-(4-nitrophenyl) grou...

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Veröffentlicht in:	Journal of pharmaceutical sciences 1980-01, Vol.69 (1), p.107-110
Hauptverfasser:	Burch, Homer A., White, Ronald E., Wright, George C., Goldenberg, Marvin M.
Format:	Artikel
Sprache:	eng
Schlagworte:	2- (dimethyl)propyl esters of 5-substituted phenyl-2-furancarboxylic acids Animals Chemical Phenomena Chemistry Furans - chemical synthesis Ileum - drug effects Parasympatholytics - chemical synthesis Parasympatholytics - pharmacology Phenylfurans-3-diethylamino -2 Phenylfurans—3-diethylamino -2,2- (dimethyl)propyl esters of 5-substituted phenyl-2-furancarboxylic acids, synthesis, potential use as spasmolytic agents potential use as spasmolytic agents Rabbits Spasmolytic agents-3-diethylamino-2 Spasmolytic agents—3-diethylamino-2,2-(dimethyl)propyl esters of 5-substituted phenyl-2-furancarboxylic acids, synthesis and pharmacological properties synthesis synthesis and pharmacological properties
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Zusammenfassung:	A series of 3-diethylamino-2,2-(dimethyl)propyl 5-substituted phenyl-2-furancarboxylates was prepared and found to be pharmacologically active in vitro as GI tract nonanticholinergic smooth muscle spasmolytic agents. One of the more active compounds in the series contained the 5-(4-nitrophenyl) group.
ISSN:	0022-3549 1520-6017
DOI:	10.1002/jps.2600690135