Correlation of a specific chromosomal marker, 21q-, and retroviral indicators in patients with thrombocythemia
A chromosomal anomaly, 21 q-, has been found in association with retroviral indicators in patients with myeloproliferative disorders (MPD) including polycythemia vera (PV), essential thrombocythemia (ET), chronic myelocytic leukemia (CML) and acute non-lymphocytic leukemia (ANLL). The viral indicato...
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| Veröffentlicht in: | Cancer letters 1979, Vol.6 (1), p.51-56 |
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| container_end_page | 56 |
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| container_issue | 1 |
| container_start_page | 51 |
| container_title | Cancer letters |
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| creator | Fuscaldo, Kathryn E. Erlick, Barry J. Fuscaldo, Anthony A. Brodsky, Isadore Zaccaria, Alfonso |
| description | A chromosomal anomaly, 21 q-, has been found in association with retroviral indicators in patients with myeloproliferative disorders (MPD) including polycythemia vera (PV), essential thrombocythemia (ET), chronic myelocytic leukemia (CML) and acute non-lymphocytic leukemia (ANLL). The viral indicators are found in platelet homogenates of thrombocythemic patients. Evidence is presented from 2 laboratories (Philadelphia, USA and Bologna, Italy) for the 21q- deletion in MPD patients. Thirty patients evaluated for the presence of both viral and chromosomal markers in Philadelphia showed positive correlations. |
| doi_str_mv | 10.1016/S0304-3835(79)80020-8 |
| format | Article |
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The viral indicators are found in platelet homogenates of thrombocythemic patients. Evidence is presented from 2 laboratories (Philadelphia, USA and Bologna, Italy) for the 21q- deletion in MPD patients. Thirty patients evaluated for the presence of both viral and chromosomal markers in Philadelphia showed positive correlations.</description><identifier>ISSN: 0304-3835</identifier><identifier>EISSN: 1872-7980</identifier><identifier>DOI: 10.1016/S0304-3835(79)80020-8</identifier><identifier>PMID: 94552</identifier><language>eng</language><publisher>Ireland: Elsevier Ireland Ltd</publisher><subject>Animals ; Blood Platelets - analysis ; Chromosome Deletion ; Chromosomes, Human, 21-22 and Y ; Genetic Markers ; Humans ; Inclusion Bodies, Viral - analysis ; Leukemia, Myeloid - etiology ; Myeloproliferative Disorders - etiology ; Polycythemia Vera - etiology ; Retroviridae ; RNA-Directed DNA Polymerase - blood ; Thrombocytosis - etiology ; Tumor Virus Infections - diagnosis</subject><ispartof>Cancer letters, 1979, Vol.6 (1), p.51-56</ispartof><rights>1979</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c273t-3a8794e45daed6d25692c4a21311d81580837fbb38b7c75fffac34dde8e12e8c3</citedby><cites>FETCH-LOGICAL-c273t-3a8794e45daed6d25692c4a21311d81580837fbb38b7c75fffac34dde8e12e8c3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/S0304-3835(79)80020-8$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,778,782,3539,4012,27910,27911,27912,45982</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/94552$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Fuscaldo, Kathryn E.</creatorcontrib><creatorcontrib>Erlick, Barry J.</creatorcontrib><creatorcontrib>Fuscaldo, Anthony A.</creatorcontrib><creatorcontrib>Brodsky, Isadore</creatorcontrib><creatorcontrib>Zaccaria, Alfonso</creatorcontrib><title>Correlation of a specific chromosomal marker, 21q-, and retroviral indicators in patients with thrombocythemia</title><title>Cancer letters</title><addtitle>Cancer Lett</addtitle><description>A chromosomal anomaly, 21 q-, has been found in association with retroviral indicators in patients with myeloproliferative disorders (MPD) including polycythemia vera (PV), essential thrombocythemia (ET), chronic myelocytic leukemia (CML) and acute non-lymphocytic leukemia (ANLL). The viral indicators are found in platelet homogenates of thrombocythemic patients. Evidence is presented from 2 laboratories (Philadelphia, USA and Bologna, Italy) for the 21q- deletion in MPD patients. Thirty patients evaluated for the presence of both viral and chromosomal markers in Philadelphia showed positive correlations.</description><subject>Animals</subject><subject>Blood Platelets - analysis</subject><subject>Chromosome Deletion</subject><subject>Chromosomes, Human, 21-22 and Y</subject><subject>Genetic Markers</subject><subject>Humans</subject><subject>Inclusion Bodies, Viral - analysis</subject><subject>Leukemia, Myeloid - etiology</subject><subject>Myeloproliferative Disorders - etiology</subject><subject>Polycythemia Vera - etiology</subject><subject>Retroviridae</subject><subject>RNA-Directed DNA Polymerase - blood</subject><subject>Thrombocytosis - etiology</subject><subject>Tumor Virus Infections - diagnosis</subject><issn>0304-3835</issn><issn>1872-7980</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1979</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkN1LHDEUxYN0qav2LxAhT6WCY_Mx2WSeSlm0Cgs-WJ9DJrnDpp2ZzCZZxf--2Q987dO9cM49l_ND6IqSW0ro4vsz4aSuuOLim2yuFSGMVOoEzamSrJKNIp_Q_MNyis5S-kMIEbUUn9GsqYVgczQuQ4zQm-zDiEOHDU4TWN95i-06hiGkMJgeDyb-hXiDGd1UN9iMDkfIMbz6WEQ_Om9NDjGVFU8lC8ac8JvPa5x3IW2w73kNgzcXaNaZPsGX4zxHL_d3v5cP1erp1-Py56qyTPJccaNkU0MtnAG3cEwsGmZrwyin1CkqFFFcdm3LVSutFF3XGctr50ABZaAsP0dfD7lTDJstpKwHnyz0vRkhbJOWdaNoQ2UxioPRxpBShE5P0Ze275oSvaOs95T1DqGWjd5T1qrcXR4fbNsB3MfVHmtRfxxUKB1fPUSdbIFiwfkINmsX_H_y_wEi0o3l</recordid><startdate>1979</startdate><enddate>1979</enddate><creator>Fuscaldo, Kathryn E.</creator><creator>Erlick, Barry J.</creator><creator>Fuscaldo, Anthony A.</creator><creator>Brodsky, Isadore</creator><creator>Zaccaria, Alfonso</creator><general>Elsevier Ireland Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>1979</creationdate><title>Correlation of a specific chromosomal marker, 21q-, and retroviral indicators in patients with thrombocythemia</title><author>Fuscaldo, Kathryn E. ; Erlick, Barry J. ; Fuscaldo, Anthony A. ; Brodsky, Isadore ; Zaccaria, Alfonso</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c273t-3a8794e45daed6d25692c4a21311d81580837fbb38b7c75fffac34dde8e12e8c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1979</creationdate><topic>Animals</topic><topic>Blood Platelets - analysis</topic><topic>Chromosome Deletion</topic><topic>Chromosomes, Human, 21-22 and Y</topic><topic>Genetic Markers</topic><topic>Humans</topic><topic>Inclusion Bodies, Viral - analysis</topic><topic>Leukemia, Myeloid - etiology</topic><topic>Myeloproliferative Disorders - etiology</topic><topic>Polycythemia Vera - etiology</topic><topic>Retroviridae</topic><topic>RNA-Directed DNA Polymerase - blood</topic><topic>Thrombocytosis - etiology</topic><topic>Tumor Virus Infections - diagnosis</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Fuscaldo, Kathryn E.</creatorcontrib><creatorcontrib>Erlick, Barry J.</creatorcontrib><creatorcontrib>Fuscaldo, Anthony A.</creatorcontrib><creatorcontrib>Brodsky, Isadore</creatorcontrib><creatorcontrib>Zaccaria, Alfonso</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Cancer letters</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Fuscaldo, Kathryn E.</au><au>Erlick, Barry J.</au><au>Fuscaldo, Anthony A.</au><au>Brodsky, Isadore</au><au>Zaccaria, Alfonso</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Correlation of a specific chromosomal marker, 21q-, and retroviral indicators in patients with thrombocythemia</atitle><jtitle>Cancer letters</jtitle><addtitle>Cancer Lett</addtitle><date>1979</date><risdate>1979</risdate><volume>6</volume><issue>1</issue><spage>51</spage><epage>56</epage><pages>51-56</pages><issn>0304-3835</issn><eissn>1872-7980</eissn><abstract>A chromosomal anomaly, 21 q-, has been found in association with retroviral indicators in patients with myeloproliferative disorders (MPD) including polycythemia vera (PV), essential thrombocythemia (ET), chronic myelocytic leukemia (CML) and acute non-lymphocytic leukemia (ANLL). The viral indicators are found in platelet homogenates of thrombocythemic patients. Evidence is presented from 2 laboratories (Philadelphia, USA and Bologna, Italy) for the 21q- deletion in MPD patients. Thirty patients evaluated for the presence of both viral and chromosomal markers in Philadelphia showed positive correlations.</abstract><cop>Ireland</cop><pub>Elsevier Ireland Ltd</pub><pmid>94552</pmid><doi>10.1016/S0304-3835(79)80020-8</doi><tpages>6</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0304-3835 |
| ispartof | Cancer letters, 1979, Vol.6 (1), p.51-56 |
| issn | 0304-3835 1872-7980 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_74981917 |
| source | MEDLINE; ScienceDirect Journals (5 years ago - present) |
| subjects | Animals Blood Platelets - analysis Chromosome Deletion Chromosomes, Human, 21-22 and Y Genetic Markers Humans Inclusion Bodies, Viral - analysis Leukemia, Myeloid - etiology Myeloproliferative Disorders - etiology Polycythemia Vera - etiology Retroviridae RNA-Directed DNA Polymerase - blood Thrombocytosis - etiology Tumor Virus Infections - diagnosis |
| title | Correlation of a specific chromosomal marker, 21q-, and retroviral indicators in patients with thrombocythemia |
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