Correlation of a specific chromosomal marker, 21q-, and retroviral indicators in patients with thrombocythemia

A chromosomal anomaly, 21 q-, has been found in association with retroviral indicators in patients with myeloproliferative disorders (MPD) including polycythemia vera (PV), essential thrombocythemia (ET), chronic myelocytic leukemia (CML) and acute non-lymphocytic leukemia (ANLL). The viral indicato...

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Veröffentlicht in:	Cancer letters 1979, Vol.6 (1), p.51-56
Hauptverfasser:	Fuscaldo, Kathryn E., Erlick, Barry J., Fuscaldo, Anthony A., Brodsky, Isadore, Zaccaria, Alfonso
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Blood Platelets - analysis Chromosome Deletion Chromosomes, Human, 21-22 and Y Genetic Markers Humans Inclusion Bodies, Viral - analysis Leukemia, Myeloid - etiology Myeloproliferative Disorders - etiology Polycythemia Vera - etiology Retroviridae RNA-Directed DNA Polymerase - blood Thrombocytosis - etiology Tumor Virus Infections - diagnosis
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Zusammenfassung:	A chromosomal anomaly, 21 q-, has been found in association with retroviral indicators in patients with myeloproliferative disorders (MPD) including polycythemia vera (PV), essential thrombocythemia (ET), chronic myelocytic leukemia (CML) and acute non-lymphocytic leukemia (ANLL). The viral indicators are found in platelet homogenates of thrombocythemic patients. Evidence is presented from 2 laboratories (Philadelphia, USA and Bologna, Italy) for the 21q- deletion in MPD patients. Thirty patients evaluated for the presence of both viral and chromosomal markers in Philadelphia showed positive correlations.
ISSN:	0304-3835 1872-7980
DOI:	10.1016/S0304-3835(79)80020-8