Influence of glucose on cephalic-vagal-stimulated gastric acid secretion in man

Gastric acid secretion was stimulated by the preparation and anticipation of a self-selected meal in five healthy male subjects. The purpose of the investigation was to determine whether intravenous (IV) or intraduodenally (ID) administered glucose solution given during the test hour of meal preparation and anticipation altered psychically stimulated acid secretion. Each subject had seven self-selected meals and received in a randomized, blinded manner the following IV or ID solutions during the test hour: IV normal saline (200 ml/hr and 1000 ml/hr; N = 2); IV glucose, 10 g (200 ml/hr, 5% D/W; N = 1); IV glucose, 25 g (250 ml/hr, 10% D/W; N = 1); IV glucose, 100 g (1000 ml/hr 10% D/W: N = 1); ID normal saline (1000 ml/hr; N = 1) and ID glucose, 30-100 g (600-2000 ml/hr, 5% D/W; N = 1). Analysis of results revealed that only ID glucose significantly inhibited psychically stimulated acid secretion at doses and resultant plasma glucose concentrations considered physiological.