The absorption and excretion rates of a new pyrido[1,2-a] pyrimidine derivative (Chinoin 123) in rats
The metabolism and absorption of a potential new drug, Chinoin 123, having an antiatherogenic effect, were studied in rats. Using different methods it was confirmed that the main metabolite of the drug is a free acid form, formed by ester hydrolysis. In Sartorius Resorption Model only the gastric ab...
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| Veröffentlicht in: | Pharmazie 1979, Vol.34 (9), p.551-556 |
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| container_title | Pharmazie |
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| creator | Szentmiklósi, P Marton, S Kovács, M Gyarmati, L |
| description | The metabolism and absorption of a potential new drug, Chinoin 123, having an antiatherogenic effect, were studied in rats. Using different methods it was confirmed that the main metabolite of the drug is a free acid form, formed by ester hydrolysis. In Sartorius Resorption Model only the gastric absorption was confirmed and calculated. In vivo experiments in rats showed rather good absorption. The blood and urine concentrations of the drug were determined. |
| format | Article |
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Using different methods it was confirmed that the main metabolite of the drug is a free acid form, formed by ester hydrolysis. In Sartorius Resorption Model only the gastric absorption was confirmed and calculated. In vivo experiments in rats showed rather good absorption. The blood and urine concentrations of the drug were determined.</description><identifier>ISSN: 0031-7144</identifier><identifier>PMID: 542489</identifier><language>eng</language><publisher>Germany</publisher><subject>Administration, Oral ; Animals ; Female ; Intestinal Absorption ; Male ; Pyridines - administration & dosage ; Pyridines - metabolism ; Pyrimidines - administration & dosage ; Pyrimidines - metabolism ; Rats ; Time Factors</subject><ispartof>Pharmazie, 1979, Vol.34 (9), p.551-556</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,4010</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/542489$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Szentmiklósi, P</creatorcontrib><creatorcontrib>Marton, S</creatorcontrib><creatorcontrib>Kovács, M</creatorcontrib><creatorcontrib>Gyarmati, L</creatorcontrib><title>The absorption and excretion rates of a new pyrido[1,2-a] pyrimidine derivative (Chinoin 123) in rats</title><title>Pharmazie</title><addtitle>Pharmazie</addtitle><description>The metabolism and absorption of a potential new drug, Chinoin 123, having an antiatherogenic effect, were studied in rats. Using different methods it was confirmed that the main metabolite of the drug is a free acid form, formed by ester hydrolysis. In Sartorius Resorption Model only the gastric absorption was confirmed and calculated. In vivo experiments in rats showed rather good absorption. The blood and urine concentrations of the drug were determined.</description><subject>Administration, Oral</subject><subject>Animals</subject><subject>Female</subject><subject>Intestinal Absorption</subject><subject>Male</subject><subject>Pyridines - administration & dosage</subject><subject>Pyridines - metabolism</subject><subject>Pyrimidines - administration & dosage</subject><subject>Pyrimidines - metabolism</subject><subject>Rats</subject><subject>Time Factors</subject><issn>0031-7144</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1979</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNotkEtLAzEUhbPwVav_wEVWouBAXtNkllJ8QcFNXYkMN8kdGmmTMZlW--8tbVeHDw4fnHNCRoxJXmmu1AW5LOWbMTERE3NOzmollGlGBOcLpGBLyv0QUqQQPcU_l3FPGQYsNHUUaMRf2m9z8OmTP4gKvva0Cj5EpB5z2MAQNkjvposQU4iUC3lPw95RrshpB8uC18cck4_np_n0tZq9v7xNH2dVL1g9VGCsB3CN8kZp5gS3jDMtJ6KzUnEjG-u4r7XgUjvjjHYWfMcNa6R3Qkgpx-T24O1z-lljGdpVKA6XS4iY1qXVqtFcq3pXvDkW13aFvu13UyBv28Mt8h_dM1xu</recordid><startdate>1979</startdate><enddate>1979</enddate><creator>Szentmiklósi, P</creator><creator>Marton, S</creator><creator>Kovács, M</creator><creator>Gyarmati, L</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope></search><sort><creationdate>1979</creationdate><title>The absorption and excretion rates of a new pyrido[1,2-a] pyrimidine derivative (Chinoin 123) in rats</title><author>Szentmiklósi, P ; Marton, S ; Kovács, M ; Gyarmati, L</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-p205t-a8bdaac94d8470c21b0107362fb341839bc1d572137c8c87cbadf18093dc22333</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1979</creationdate><topic>Administration, Oral</topic><topic>Animals</topic><topic>Female</topic><topic>Intestinal Absorption</topic><topic>Male</topic><topic>Pyridines - administration & dosage</topic><topic>Pyridines - metabolism</topic><topic>Pyrimidines - administration & dosage</topic><topic>Pyrimidines - metabolism</topic><topic>Rats</topic><topic>Time Factors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Szentmiklósi, P</creatorcontrib><creatorcontrib>Marton, S</creatorcontrib><creatorcontrib>Kovács, M</creatorcontrib><creatorcontrib>Gyarmati, L</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><jtitle>Pharmazie</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Szentmiklósi, P</au><au>Marton, S</au><au>Kovács, M</au><au>Gyarmati, L</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The absorption and excretion rates of a new pyrido[1,2-a] pyrimidine derivative (Chinoin 123) in rats</atitle><jtitle>Pharmazie</jtitle><addtitle>Pharmazie</addtitle><date>1979</date><risdate>1979</risdate><volume>34</volume><issue>9</issue><spage>551</spage><epage>556</epage><pages>551-556</pages><issn>0031-7144</issn><abstract>The metabolism and absorption of a potential new drug, Chinoin 123, having an antiatherogenic effect, were studied in rats. Using different methods it was confirmed that the main metabolite of the drug is a free acid form, formed by ester hydrolysis. In Sartorius Resorption Model only the gastric absorption was confirmed and calculated. In vivo experiments in rats showed rather good absorption. The blood and urine concentrations of the drug were determined.</abstract><cop>Germany</cop><pmid>542489</pmid><tpages>6</tpages></addata></record> |
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| identifier | ISSN: 0031-7144 |
| ispartof | Pharmazie, 1979, Vol.34 (9), p.551-556 |
| issn | 0031-7144 |
| language | eng |
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| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals |
| subjects | Administration, Oral Animals Female Intestinal Absorption Male Pyridines - administration & dosage Pyridines - metabolism Pyrimidines - administration & dosage Pyrimidines - metabolism Rats Time Factors |
| title | The absorption and excretion rates of a new pyrido[1,2-a] pyrimidine derivative (Chinoin 123) in rats |
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