The absorption and excretion rates of a new pyrido[1,2-a] pyrimidine derivative (Chinoin 123) in rats

The metabolism and absorption of a potential new drug, Chinoin 123, having an antiatherogenic effect, were studied in rats. Using different methods it was confirmed that the main metabolite of the drug is a free acid form, formed by ester hydrolysis. In Sartorius Resorption Model only the gastric ab...

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Veröffentlicht in:	Pharmazie 1979, Vol.34 (9), p.551-556
Hauptverfasser:	Szentmiklósi, P, Marton, S, Kovács, M, Gyarmati, L
Format:	Artikel
Sprache:	eng
Schlagworte:	Administration, Oral Animals Female Intestinal Absorption Male Pyridines - administration & dosage Pyridines - metabolism Pyrimidines - administration & dosage Pyrimidines - metabolism Rats Time Factors
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Zusammenfassung:	The metabolism and absorption of a potential new drug, Chinoin 123, having an antiatherogenic effect, were studied in rats. Using different methods it was confirmed that the main metabolite of the drug is a free acid form, formed by ester hydrolysis. In Sartorius Resorption Model only the gastric absorption was confirmed and calculated. In vivo experiments in rats showed rather good absorption. The blood and urine concentrations of the drug were determined.
ISSN:	0031-7144