The mechanism of protein secretion across membranes

Many secreted proteins are synthesised as a large precursor with an additional hydrophobic N-terminal signal sequence that is cleaved by a membrane-bound enzyme. The proteins are secreted as nascent chains. The work leading to the current models of protein secretion is reviewed and the value of bact...

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Veröffentlicht in:	Nature (London) 1980-01, Vol.283 (5746), p.433-438
Hauptverfasser:	Davis, Bernard D, Tai, Phang-C
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Bacteria - genetics Bacteria - metabolism Bacterial Proteins - metabolism Cell Membrane - metabolism Energy Metabolism Humanities and Social Sciences Intracellular Membranes - metabolism Membranes - metabolism multidisciplinary Protein Biosynthesis Protein Precursors - metabolism Proteins - metabolism review-article Ribosomes - metabolism Science Science (multidisciplinary)
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Beschreibung
Zusammenfassung:	Many secreted proteins are synthesised as a large precursor with an additional hydrophobic N-terminal signal sequence that is cleaved by a membrane-bound enzyme. The proteins are secreted as nascent chains. The work leading to the current models of protein secretion is reviewed and the value of bacterial systems in the study of protein transfer across membranes is stressed.
ISSN:	0028-0836 1476-4687
DOI:	10.1038/283433a0