Potential antiinflammatory compounds. 2. Acidic antiinflammatory 1,2-benzisoxazoles

A number of 1,2-benzisoxazoles, substituted in the 3 position with 4-substituted phenyl groups and in the 5--7 positions with acetic and propionic acid residues, have been synthesized and tested in the rat carrageenan foot edema assay. Activity has been found in the 6- and 7-substituted acids.

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Bibliographische Detailangaben
Veröffentlicht in:	Journal of medicinal chemistry 1979-12, Vol.22 (12), p.1554-1558
Hauptverfasser:	Saunders, J. C, Williamson, W. R. N
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Anti-Inflammatory Agents - chemical synthesis Carrageenan Edema - chemically induced Edema - physiopathology Isoxazoles - chemical synthesis Isoxazoles - pharmacology Oxazoles - chemical synthesis Rats Structure-Activity Relationship
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Beschreibung
Zusammenfassung:	A number of 1,2-benzisoxazoles, substituted in the 3 position with 4-substituted phenyl groups and in the 5--7 positions with acetic and propionic acid residues, have been synthesized and tested in the rat carrageenan foot edema assay. Activity has been found in the 6- and 7-substituted acids.
ISSN:	0022-2623 1520-4804
DOI:	10.1021/jm00198a026