Inhibition of the Growth of Murine Malignant Melanoma by Polyinosinic-Polycytidylic Acid

Polyinosinic-polycytidylic acid (poly I. poly C) markedly inhibits the growth of both light grey and jet black B-16 malignant melanomas borne by C-57 black mice. The survival time of mice bearing B-16 malignant melanomas is prolonged by treatment with poly I. poly C. Inocula of tumor cells ordinaril...

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Veröffentlicht in:	Journal of investigative dermatology 1971-01, Vol.56 (1), p.33-38
Hauptverfasser:	Bart, Robert S., Kopf, Alfred W., Silagi, Selma
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antineoplastic Agents - therapeutic use Female Melanoma - drug therapy Melanoma - mortality Melanoma - pathology Melanosis Mice Neoplasm Metastasis Neoplasm Transplantation Poly I-C - therapeutic use Polynucleotides - therapeutic use Skin Neoplasms - drug therapy Skin Neoplasms - mortality Skin Neoplasms - pathology
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Zusammenfassung:	Polyinosinic-polycytidylic acid (poly I. poly C) markedly inhibits the growth of both light grey and jet black B-16 malignant melanomas borne by C-57 black mice. The survival time of mice bearing B-16 malignant melanomas is prolonged by treatment with poly I. poly C. Inocula of tumor cells ordinarily sufficient to result inevitably in fatal melanomatosis in all control mice do not kill all the mice which have been treated with poly I. poly C.
ISSN:	0022-202X 1523-1747
DOI:	10.1111/1523-1747.ep12291892