Total Hydroxyproline Levels in Sera of Patients with Periodontal Disease

Measurements of total hydroxyproline levels in human sera were carried out on 11 clinical healthy subjects ranging from 23 to 27 years of age, and in 57 patients with periodontal disease ranging from 16 to 64 years of age. The correlations between hydroxyproline levels and a few indicies of periodontal disease were discussed in order to estimate hydroxyproline levels as an index of periodontal tissue destruction. The following results were obtained. 1. Hydroxyproline levels in sera were constant regardless of age group. 2. Hydroxyproline levels in sera of patients were higher than the levels of clinical healthy subjects. But there was no significant difference in them. 3. No significant correlations were found out between indices of periodontal disease, i. e. Gingival Bone counts, Gingival scores, Bone scores and Salivary leucocyte counts, and total hydroxyproline levels in sera. But there was seen a significant correlation only between Bone scores and hydroxyproline levels in sera of clinical healthy subjects. Some factors concerning hydroxyproline levels in sera are to be studied.