Identification of Hydrazine derived from Hydralazine in Experimental Animals
The liberation of hydrazine from hydralazine was demonstrated in rabbit urine, in rat plasma and in a rat enzyme system. The identification of hydrazine in rabbit urine was performed by comparison of the gas chromatogram and mass spectrum of its benzalazine derivative with those of an authentic samp...
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| Veröffentlicht in: | Chemical & pharmaceutical bulletin 1979/08/25, Vol.27(8), pp.1938-1941 |
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| container_end_page | 1941 |
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| container_issue | 8 |
| container_start_page | 1938 |
| container_title | Chemical & pharmaceutical bulletin |
| container_volume | 27 |
| creator | NODA, ATSUKO MATSUYAMA, KENJI YEN, SHUHWAI OTSUJI, NOZOMU IGUCHI, SADAO NODA, HIROSHI |
| description | The liberation of hydrazine from hydralazine was demonstrated in rabbit urine, in rat plasma and in a rat enzyme system. The identification of hydrazine in rabbit urine was performed by comparison of the gas chromatogram and mass spectrum of its benzalazine derivative with those of an authentic sample. Small amounts of hydrazine extracted from rat plasma and the rat enzyme system were detected by mass fragmentography using 15N-hydrazine. |
| doi_str_mv | 10.1248/cpb.27.1938 |
| format | Article |
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The identification of hydrazine in rabbit urine was performed by comparison of the gas chromatogram and mass spectrum of its benzalazine derivative with those of an authentic sample. Small amounts of hydrazine extracted from rat plasma and the rat enzyme system were detected by mass fragmentography using 15N-hydrazine.</description><identifier>ISSN: 0009-2363</identifier><identifier>EISSN: 1347-5223</identifier><identifier>DOI: 10.1248/cpb.27.1938</identifier><identifier>PMID: 540361</identifier><language>eng</language><publisher>Japan: The Pharmaceutical Society of Japan</publisher><subject>Animals ; Chemical Phenomena ; Chemistry ; determination by GC and GC-MS ; Hydralazine - metabolism ; Hydrazines - blood ; Hydrazines - isolation & purification ; Hydrazines - urine ; Male ; Rabbits ; Rats</subject><ispartof>Chemical and Pharmaceutical Bulletin, 1979/08/25, Vol.27(8), pp.1938-1941</ispartof><rights>The Pharmaceutical Society of Japan</rights><rights>Copyright Japan Science and Technology Agency 1979</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4918-36d901d0a55be1feba8b809defe53ffcbcb8d090185c92cfb99ca1d487ee3a383</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,1883,4024,27923,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/540361$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>NODA, ATSUKO</creatorcontrib><creatorcontrib>MATSUYAMA, KENJI</creatorcontrib><creatorcontrib>YEN, SHUHWAI</creatorcontrib><creatorcontrib>OTSUJI, NOZOMU</creatorcontrib><creatorcontrib>IGUCHI, SADAO</creatorcontrib><creatorcontrib>NODA, HIROSHI</creatorcontrib><title>Identification of Hydrazine derived from Hydralazine in Experimental Animals</title><title>Chemical & pharmaceutical bulletin</title><addtitle>Chem. Pharm. Bull.</addtitle><description>The liberation of hydrazine from hydralazine was demonstrated in rabbit urine, in rat plasma and in a rat enzyme system. The identification of hydrazine in rabbit urine was performed by comparison of the gas chromatogram and mass spectrum of its benzalazine derivative with those of an authentic sample. 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Pharm. Bull.</addtitle><date>1979</date><risdate>1979</risdate><volume>27</volume><issue>8</issue><spage>1938</spage><epage>1941</epage><pages>1938-1941</pages><issn>0009-2363</issn><eissn>1347-5223</eissn><abstract>The liberation of hydrazine from hydralazine was demonstrated in rabbit urine, in rat plasma and in a rat enzyme system. The identification of hydrazine in rabbit urine was performed by comparison of the gas chromatogram and mass spectrum of its benzalazine derivative with those of an authentic sample. Small amounts of hydrazine extracted from rat plasma and the rat enzyme system were detected by mass fragmentography using 15N-hydrazine.</abstract><cop>Japan</cop><pub>The Pharmaceutical Society of Japan</pub><pmid>540361</pmid><doi>10.1248/cpb.27.1938</doi><tpages>4</tpages><oa>free_for_read</oa></addata></record> |
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| identifier | ISSN: 0009-2363 |
| ispartof | Chemical and Pharmaceutical Bulletin, 1979/08/25, Vol.27(8), pp.1938-1941 |
| issn | 0009-2363 1347-5223 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_74942133 |
| source | J-STAGE Free; MEDLINE; EZB-FREE-00999 freely available EZB journals; Free Full-Text Journals in Chemistry |
| subjects | Animals Chemical Phenomena Chemistry determination by GC and GC-MS Hydralazine - metabolism Hydrazines - blood Hydrazines - isolation & purification Hydrazines - urine Male Rabbits Rats |
| title | Identification of Hydrazine derived from Hydralazine in Experimental Animals |
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