Identification of Hydrazine derived from Hydralazine in Experimental Animals

Identification of Hydrazine derived from Hydralazine in Experimental Animals

The liberation of hydrazine from hydralazine was demonstrated in rabbit urine, in rat plasma and in a rat enzyme system. The identification of hydrazine in rabbit urine was performed by comparison of the gas chromatogram and mass spectrum of its benzalazine derivative with those of an authentic samp...

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Veröffentlicht in:Chemical & pharmaceutical bulletin 1979/08/25, Vol.27(8), pp.1938-1941
Hauptverfasser: NODA, ATSUKO, MATSUYAMA, KENJI, YEN, SHUHWAI, OTSUJI, NOZOMU, IGUCHI, SADAO, NODA, HIROSHI
Format: Artikel
Sprache:eng
Schlagworte:
Animals
Chemical Phenomena
Chemistry
determination by GC and GC-MS
Hydralazine - metabolism
Hydrazines - blood
Hydrazines - isolation & purification
Hydrazines - urine
Male
Rabbits
Rats
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Zusammenfassung:The liberation of hydrazine from hydralazine was demonstrated in rabbit urine, in rat plasma and in a rat enzyme system. The identification of hydrazine in rabbit urine was performed by comparison of the gas chromatogram and mass spectrum of its benzalazine derivative with those of an authentic sample. Small amounts of hydrazine extracted from rat plasma and the rat enzyme system were detected by mass fragmentography using 15N-hydrazine.
ISSN:0009-2363
1347-5223
DOI:10.1248/cpb.27.1938