Effect of zinc on hyperammonemia in sickle cell anemia subjects

An increase in plasma ammonia level in human volunteers on restricted zinc intake, and in zinc‐deficient rats, has recently been reported. Inasmuch as zinc deficiency has been observed in sickle cell anemia patients, we measured plasma ammonia levels in such subjects. In this report we document hype...

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Veröffentlicht in:American journal of hematology 1979-01, Vol.7 (4), p.323-327
Hauptverfasser: Prasad, Ananda S., Rabbani, Parviz, Warth, James A.
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container_title American journal of hematology
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creator Prasad, Ananda S.
Rabbani, Parviz
Warth, James A.
description An increase in plasma ammonia level in human volunteers on restricted zinc intake, and in zinc‐deficient rats, has recently been reported. Inasmuch as zinc deficiency has been observed in sickle cell anemia patients, we measured plasma ammonia levels in such subjects. In this report we document hyperammonemia in sickle cell anemia patients that was corrected with zinc therapy.
doi_str_mv 10.1002/ajh.2830070404
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subjects Adolescent
Adult
Ammonia - blood
AMP Deaminase - analysis
Anemia, Sickle Cell - blood
Anemia, Sickle Cell - drug therapy
Blood Urea Nitrogen
Female
Humans
hyperammonemia
Liver Diseases - etiology
Male
sickle cell anemia
zinc
Zinc - deficiency
Zinc - pharmacology
Zinc - therapeutic use
title Effect of zinc on hyperammonemia in sickle cell anemia subjects
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