Effect of zinc on hyperammonemia in sickle cell anemia subjects

An increase in plasma ammonia level in human volunteers on restricted zinc intake, and in zinc‐deficient rats, has recently been reported. Inasmuch as zinc deficiency has been observed in sickle cell anemia patients, we measured plasma ammonia levels in such subjects. In this report we document hype...

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Veröffentlicht in:	American journal of hematology 1979-01, Vol.7 (4), p.323-327
Hauptverfasser:	Prasad, Ananda S., Rabbani, Parviz, Warth, James A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Adult Ammonia - blood AMP Deaminase - analysis Anemia, Sickle Cell - blood Anemia, Sickle Cell - drug therapy Blood Urea Nitrogen Female Humans hyperammonemia Liver Diseases - etiology Male sickle cell anemia zinc Zinc - deficiency Zinc - pharmacology Zinc - therapeutic use
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Zusammenfassung:	An increase in plasma ammonia level in human volunteers on restricted zinc intake, and in zinc‐deficient rats, has recently been reported. Inasmuch as zinc deficiency has been observed in sickle cell anemia patients, we measured plasma ammonia levels in such subjects. In this report we document hyperammonemia in sickle cell anemia patients that was corrected with zinc therapy.
ISSN:	0361-8609 1096-8652
DOI:	10.1002/ajh.2830070404