The epidemiology of Wilson's disease in the German Democratic Republic and current problems from the viewpoint of population genetics

The epidemiology of Wilson's disease in the German Democratic Republic and current problems from the viewpoint of population genetics

Between 1949 and Nov. 30, 1977 a total of 123 cases of Wilson's disease have been registered in the GDR. Using the available statistics the incidence rate of the disease is assumed to be about 2.9/100,000, the gene frequency approx. 0.53 per cent and the heterozygote incidence 1.05 per cent, su...

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Veröffentlicht in:Psychiatrie, Neurologie, und medizinische Psychologie Neurologie, und medizinische Psychologie, 1979-07, Vol.31 (7), p.393-400
Hauptverfasser: Bachmann, H, Lössner, J, Gruss, B, Ruchholtz, U
Format: Artikel
Sprache:ger
Schlagworte:
Genetics, Population
Germany, East
Hepatolenticular Degeneration - epidemiology
Hepatolenticular Degeneration - genetics
Humans
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Zusammenfassung:Between 1949 and Nov. 30, 1977 a total of 123 cases of Wilson's disease have been registered in the GDR. Using the available statistics the incidence rate of the disease is assumed to be about 2.9/100,000, the gene frequency approx. 0.53 per cent and the heterozygote incidence 1.05 per cent, supposing that the Hardy-Weinberg law applies to a large extent. Conclusions are drawn from the available material with a view to detection of the disease infuture and to genetic family counselling.
ISSN:0033-2739