Focal Glomerulosclerosis: Histological and clinical study in 13 Cases
Out of 1500 cases examined by biopsy in our clinic, 13 cases were diagnosed as focal glomerulo-sclerosis (FGS) because of more than three (>10%) sclerotic glomeruli with hyaline deposits in their biopsy specimens. Clinically, 11 patients had nephrotic syndrome and the other 2 patients had hyperte...
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| Veröffentlicht in: | Nihon Jinzo Gakkai shi 1979, Vol.21(11), pp.1207-1218 |
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| container_title | Nihon Jinzo Gakkai shi |
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| creator | Saito, Takao Furuyama, Takashi Sasaki, Yasuhiko Kyogoku, Yoshio Taguma, Yoshio Arakawa, Masahiro Yoshinaga, Kaoru Saito, Hiroshi |
| description | Out of 1500 cases examined by biopsy in our clinic, 13 cases were diagnosed as focal glomerulo-sclerosis (FGS) because of more than three (>10%) sclerotic glomeruli with hyaline deposits in their biopsy specimens. Clinically, 11 patients had nephrotic syndrome and the other 2 patients had hypertension. All patients were resistant to the therapy, and 4 patients took downhill courses to renal insufficiency. The glomerular sclerosis index (G. S. I.) and the tubular atrophy index (T/S) respectively devised by us were mesured in every biopsy specimen. There was a statistically significant cor-relation between them (r=-0.78, p |
| doi_str_mv | 10.14842/jpnjnephrol1959.21.11_1207 |
| format | Article |
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Clinically, 11 patients had nephrotic syndrome and the other 2 patients had hypertension. All patients were resistant to the therapy, and 4 patients took downhill courses to renal insufficiency. The glomerular sclerosis index (G. S. I.) and the tubular atrophy index (T/S) respectively devised by us were mesured in every biopsy specimen. There was a statistically significant cor-relation between them (r=-0.78, p<0.001).T/S indicated lower values in most of the FGS cases than in the control cases (chronic glomerulonephritis and idiopathic nephrotic syndrome except FGS) whereas the creatinine clearance were nearly equal in the two groups. It is likely that this finding is due to hemodynamic abnormalities frequently occurring FGS patients with nephrotic syndrome or with hypertension.</description><identifier>ISSN: 0385-2385</identifier><identifier>EISSN: 1884-0728</identifier><identifier>DOI: 10.14842/jpnjnephrol1959.21.11_1207</identifier><identifier>PMID: 541881</identifier><language>jpn</language><publisher>Japan: Japanese Society of Nephrology</publisher><subject>Adolescent ; Adult ; Atrophy ; Child ; Female ; Glomerulonephritis - pathology ; Glomerulosclerosis, Focal Segmental - pathology ; Humans ; Hypertension, Renal - pathology ; Kidney Glomerulus - ultrastructure ; Kidney Tubules - pathology ; Male ; Nephrotic Syndrome - pathology</subject><ispartof>The Japanese Journal of Nephrology, 1979, Vol.21(11), pp.1207-1218</ispartof><rights>Japanese Society of Nephrology</rights><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,1877,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/541881$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Saito, Takao</creatorcontrib><creatorcontrib>Furuyama, Takashi</creatorcontrib><creatorcontrib>Sasaki, Yasuhiko</creatorcontrib><creatorcontrib>Kyogoku, Yoshio</creatorcontrib><creatorcontrib>Taguma, Yoshio</creatorcontrib><creatorcontrib>Arakawa, Masahiro</creatorcontrib><creatorcontrib>Yoshinaga, Kaoru</creatorcontrib><creatorcontrib>Saito, Hiroshi</creatorcontrib><title>Focal Glomerulosclerosis: Histological and clinical study in 13 Cases</title><title>Nihon Jinzo Gakkai shi</title><addtitle>Jpn J Nephrol</addtitle><description>Out of 1500 cases examined by biopsy in our clinic, 13 cases were diagnosed as focal glomerulo-sclerosis (FGS) because of more than three (>10%) sclerotic glomeruli with hyaline deposits in their biopsy specimens. Clinically, 11 patients had nephrotic syndrome and the other 2 patients had hypertension. All patients were resistant to the therapy, and 4 patients took downhill courses to renal insufficiency. The glomerular sclerosis index (G. S. I.) and the tubular atrophy index (T/S) respectively devised by us were mesured in every biopsy specimen. There was a statistically significant cor-relation between them (r=-0.78, p<0.001).T/S indicated lower values in most of the FGS cases than in the control cases (chronic glomerulonephritis and idiopathic nephrotic syndrome except FGS) whereas the creatinine clearance were nearly equal in the two groups. It is likely that this finding is due to hemodynamic abnormalities frequently occurring FGS patients with nephrotic syndrome or with hypertension.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Atrophy</subject><subject>Child</subject><subject>Female</subject><subject>Glomerulonephritis - pathology</subject><subject>Glomerulosclerosis, Focal Segmental - pathology</subject><subject>Humans</subject><subject>Hypertension, Renal - pathology</subject><subject>Kidney Glomerulus - ultrastructure</subject><subject>Kidney Tubules - pathology</subject><subject>Male</subject><subject>Nephrotic Syndrome - pathology</subject><issn>0385-2385</issn><issn>1884-0728</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1979</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpdkM1LAzEQxYP4VWrvHjwIgretmWzSJEcpbRWKXvQckmzW7pLdrEn34H9vpKUHYXhzeD-GeQ-hB8BzoIKSp3bo294Nuxg8SCbnBOYACgjmZ2gCQtACcyLO0QSXghUkyzWapdQYDILjknF6hS4ZzSRM0O06WO3vNz50Lo4-JOtdDKlJN-ii1j652XFP0ed69bF8Kbbvm9fl87ZoQWAoJBXYEZaPEmK5JGZR4TyY1RZjI0xVSW4Yz4_qGirGKlrXsKClKaU01olyih4Pd4cYvkeX9qprknXe696FMSlOJVkIKTN4dwRH07lKDbHpdPxRhyTZfjvYbdrrL3eyddw3OZP615oiuTI46l93J9DudFSuL38BYvtptQ</recordid><startdate>197911</startdate><enddate>197911</enddate><creator>Saito, Takao</creator><creator>Furuyama, Takashi</creator><creator>Sasaki, Yasuhiko</creator><creator>Kyogoku, Yoshio</creator><creator>Taguma, Yoshio</creator><creator>Arakawa, Masahiro</creator><creator>Yoshinaga, Kaoru</creator><creator>Saito, Hiroshi</creator><general>Japanese Society of Nephrology</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope></search><sort><creationdate>197911</creationdate><title>Focal Glomerulosclerosis</title><author>Saito, Takao ; Furuyama, Takashi ; Sasaki, Yasuhiko ; Kyogoku, Yoshio ; Taguma, Yoshio ; Arakawa, Masahiro ; Yoshinaga, Kaoru ; Saito, Hiroshi</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-j1801-9480e2557422c792b6d06d005fc00b8bdd97b57195af1d55d4ff1643b399bce83</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>jpn</language><creationdate>1979</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Atrophy</topic><topic>Child</topic><topic>Female</topic><topic>Glomerulonephritis - pathology</topic><topic>Glomerulosclerosis, Focal Segmental - pathology</topic><topic>Humans</topic><topic>Hypertension, Renal - pathology</topic><topic>Kidney Glomerulus - ultrastructure</topic><topic>Kidney Tubules - pathology</topic><topic>Male</topic><topic>Nephrotic Syndrome - pathology</topic><toplevel>online_resources</toplevel><creatorcontrib>Saito, Takao</creatorcontrib><creatorcontrib>Furuyama, Takashi</creatorcontrib><creatorcontrib>Sasaki, Yasuhiko</creatorcontrib><creatorcontrib>Kyogoku, Yoshio</creatorcontrib><creatorcontrib>Taguma, Yoshio</creatorcontrib><creatorcontrib>Arakawa, Masahiro</creatorcontrib><creatorcontrib>Yoshinaga, Kaoru</creatorcontrib><creatorcontrib>Saito, Hiroshi</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><jtitle>Nihon Jinzo Gakkai shi</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Saito, Takao</au><au>Furuyama, Takashi</au><au>Sasaki, Yasuhiko</au><au>Kyogoku, Yoshio</au><au>Taguma, Yoshio</au><au>Arakawa, Masahiro</au><au>Yoshinaga, Kaoru</au><au>Saito, Hiroshi</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Focal Glomerulosclerosis: Histological and clinical study in 13 Cases</atitle><jtitle>Nihon Jinzo Gakkai shi</jtitle><addtitle>Jpn J Nephrol</addtitle><date>1979-11</date><risdate>1979</risdate><volume>21</volume><issue>11</issue><spage>1207</spage><epage>1218</epage><pages>1207-1218</pages><issn>0385-2385</issn><eissn>1884-0728</eissn><abstract>Out of 1500 cases examined by biopsy in our clinic, 13 cases were diagnosed as focal glomerulo-sclerosis (FGS) because of more than three (>10%) sclerotic glomeruli with hyaline deposits in their biopsy specimens. Clinically, 11 patients had nephrotic syndrome and the other 2 patients had hypertension. All patients were resistant to the therapy, and 4 patients took downhill courses to renal insufficiency. The glomerular sclerosis index (G. S. I.) and the tubular atrophy index (T/S) respectively devised by us were mesured in every biopsy specimen. There was a statistically significant cor-relation between them (r=-0.78, p<0.001).T/S indicated lower values in most of the FGS cases than in the control cases (chronic glomerulonephritis and idiopathic nephrotic syndrome except FGS) whereas the creatinine clearance were nearly equal in the two groups. It is likely that this finding is due to hemodynamic abnormalities frequently occurring FGS patients with nephrotic syndrome or with hypertension.</abstract><cop>Japan</cop><pub>Japanese Society of Nephrology</pub><pmid>541881</pmid><doi>10.14842/jpnjnephrol1959.21.11_1207</doi><tpages>12</tpages><oa>free_for_read</oa></addata></record> |
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| identifier | ISSN: 0385-2385 |
| ispartof | The Japanese Journal of Nephrology, 1979, Vol.21(11), pp.1207-1218 |
| issn | 0385-2385 1884-0728 |
| language | jpn |
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| source | J-STAGE Free; MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals |
| subjects | Adolescent Adult Atrophy Child Female Glomerulonephritis - pathology Glomerulosclerosis, Focal Segmental - pathology Humans Hypertension, Renal - pathology Kidney Glomerulus - ultrastructure Kidney Tubules - pathology Male Nephrotic Syndrome - pathology |
| title | Focal Glomerulosclerosis: Histological and clinical study in 13 Cases |
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