Focal Glomerulosclerosis: Histological and clinical study in 13 Cases

Out of 1500 cases examined by biopsy in our clinic, 13 cases were diagnosed as focal glomerulo-sclerosis (FGS) because of more than three (>10%) sclerotic glomeruli with hyaline deposits in their biopsy specimens. Clinically, 11 patients had nephrotic syndrome and the other 2 patients had hypertension. All patients were resistant to the therapy, and 4 patients took downhill courses to renal insufficiency. The glomerular sclerosis index (G. S. I.) and the tubular atrophy index (T/S) respectively devised by us were mesured in every biopsy specimen. There was a statistically significant cor-relation between them (r=-0.78, p