Phagocytosis and Intracellular Fate of Sporothrix schenckii

Phagocytosis and Intracellular Fate of Sporothrix schenckii

Human polymorphonuclear leukocytes (PMNLs) phagocytized and killed yeast-phase cells of Sporothrix schenckii in vitro in the presence of 10% unheated serum. The combination of H2O2, KI, and human PMNL myeloperoxidase was lethal to yeast-phase S. schenckii. The results of this investigation suggest t...

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Veröffentlicht in:The Journal of infectious diseases 1979-12, Vol.140 (5), p.815-817
Hauptverfasser: Cunningham, K. M., Bulmer, G. S., Rhoades, E. R.
Format: Artikel
Sprache:eng
Schlagworte:
Candida albicans - immunology
Cell Survival
Chemical suspensions
Chlorides - pharmacology
Cryptococcus neoformans
Fungi
Half-Life
Hospital administration
Humans
Iodides - pharmacology
Leukocytes
Neutrophils
Neutrophils - microbiology
Peroxidase - pharmacology
Phagocytosis
Sporothrix
Sporothrix - immunology
Sporotrichosis
Yeasts
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Zusammenfassung:Human polymorphonuclear leukocytes (PMNLs) phagocytized and killed yeast-phase cells of Sporothrix schenckii in vitro in the presence of 10% unheated serum. The combination of H2O2, KI, and human PMNL myeloperoxidase was lethal to yeast-phase S. schenckii. The results of this investigation suggest that PMNLs may play an important role in host resistance to infection with S. schenckii.
ISSN:0022-1899
1537-6613
DOI:10.1093/infdis/140.5.815