Morphine like activity of some new met-enkephalin analogues

(D-Ala 2, Met 5)-Enkephalin-N-alkylamides were synthesised and tested for inhibition of electrically stimulated contraction of isolated guinea pig ileum and for analgesic activity in mice. The isopropylamide derivative had maximum activity by icv but not by ip route whereas n -propylamide had simila...

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Veröffentlicht in:	Life sciences (1973) 1979-12, Vol.25 (24), p.2023-2028
Hauptverfasser:	Mathur, K.B., Dhotre, B.J., Raghubir, R., Patnaik, G.K., Dhawan, B.N.
Format:	Artikel
Sprache:	eng
Schlagworte:	Analgesics Animals Cats Decerebrate State Endorphins - pharmacology Enkephalins - antagonists & inhibitors Enkephalins - chemical synthesis Enkephalins - pharmacology Female Guinea Pigs In Vitro Techniques Male Mice Morphine - pharmacology Muscle Contraction - drug effects Muscle, Smooth - drug effects Naloxone - pharmacology Reaction Time - drug effects Respiration - drug effects
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Beschreibung
Zusammenfassung:	(D-Ala 2, Met 5)-Enkephalin-N-alkylamides were synthesised and tested for inhibition of electrically stimulated contraction of isolated guinea pig ileum and for analgesic activity in mice. The isopropylamide derivative had maximum activity by icv but not by ip route whereas n -propylamide had similar potency by both the routes and produced less respiratory depression than morphine in anaesthetised cats.
ISSN:	0024-3205 1879-0631
DOI:	10.1016/0024-3205(79)90192-9