The functional genotype of glutathione S-transferase T1 gene is strongly associated with increased risk of idiopathic infertility in Russian men

This study was designed to investigate the association between null polymorphisms of glutathione S-transferase (GST) M1 and T1 genes and idiopathic male infertility in a Russian population including 203 infertile and 227 fertile men. The nondeletion genotype of the GSTT1 gene was found to be strongl...

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Veröffentlicht in:	Fertility and sterility 2010-08, Vol.94 (3), p.1144-1147
Hauptverfasser:	Polonikov, Alexey V., M.D, Yarosh, Sergey L., M.D, Kokhtenko, Elena V., Ph.D, Starodubova, Nina I., M.D, Pakhomov, Sergey P., M.D, Orlova, Valentina S., M.D
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Case-Control Studies Gene Deletion Gene Frequency Genetic Predisposition to Disease Genotype Glutathione Transferase - genetics Glutathione Transferase - physiology Humans Infertility, Male - genetics Internal Medicine Male Obstetrics and Gynecology Polymorphism, Genetic Risk Russia Young Adult
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Beschreibung
Zusammenfassung:	This study was designed to investigate the association between null polymorphisms of glutathione S-transferase (GST) M1 and T1 genes and idiopathic male infertility in a Russian population including 203 infertile and 227 fertile men. The nondeletion genotype of the GSTT1 gene was found to be strongly associated with the increased risk of idiopathic male infertility and asthenozoospermia.
ISSN:	0015-0282 1556-5653
DOI:	10.1016/j.fertnstert.2009.11.006