Fluorescence resonance energy transfer biosensors for cancer detection and evaluation of drug efficacy
A sensitive and specific fluorescence resonance energy transfer (FRET) biosensor was developed by Mizutani and colleagues and applied to detect the activity of BCR-ABL kinase in live cells. This biosensor allowed the detection of cancerous and drug-resistant cells, and the evaluation of kinase inhib...
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| Veröffentlicht in: | Clinical cancer research 2010-08, Vol.16 (15), p.3822-3824 |
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| container_issue | 15 |
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| container_title | Clinical cancer research |
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| creator | Lu, Shaoying Wang, Yingxiao |
| description | A sensitive and specific fluorescence resonance energy transfer (FRET) biosensor was developed by Mizutani and colleagues and applied to detect the activity of BCR-ABL kinase in live cells. This biosensor allowed the detection of cancerous and drug-resistant cells, and the evaluation of kinase inhibitor efficacy. Future biosensor development and imaging can increasingly contribute to cancer diagnosis and therapeutics. |
| doi_str_mv | 10.1158/1078-0432.CCR-10-1333 |
| format | Article |
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Future biosensor development and imaging can increasingly contribute to cancer diagnosis and therapeutics.</description><identifier>ISSN: 1078-0432</identifier><identifier>EISSN: 1557-3265</identifier><identifier>DOI: 10.1158/1078-0432.CCR-10-1333</identifier><identifier>PMID: 20670948</identifier><language>eng</language><publisher>United States</publisher><subject>Animals ; Biomarkers, Tumor - analysis ; Biosensing Techniques - methods ; Drug Resistance, Neoplasm ; Fluorescence Resonance Energy Transfer - methods ; Humans ; Neoplasms - diagnosis ; Neoplasms - drug therapy</subject><ispartof>Clinical cancer research, 2010-08, Vol.16 (15), p.3822-3824</ispartof><rights>(c) 2010 AACR.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c421t-30f4a16c366631f41e5d57e9f16b322530ef84699e3d9900058831de997656d3</citedby><cites>FETCH-LOGICAL-c421t-30f4a16c366631f41e5d57e9f16b322530ef84699e3d9900058831de997656d3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,3343,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/20670948$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Lu, Shaoying</creatorcontrib><creatorcontrib>Wang, Yingxiao</creatorcontrib><title>Fluorescence resonance energy transfer biosensors for cancer detection and evaluation of drug efficacy</title><title>Clinical cancer research</title><addtitle>Clin Cancer Res</addtitle><description>A sensitive and specific fluorescence resonance energy transfer (FRET) biosensor was developed by Mizutani and colleagues and applied to detect the activity of BCR-ABL kinase in live cells. 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Future biosensor development and imaging can increasingly contribute to cancer diagnosis and therapeutics.</description><subject>Animals</subject><subject>Biomarkers, Tumor - analysis</subject><subject>Biosensing Techniques - methods</subject><subject>Drug Resistance, Neoplasm</subject><subject>Fluorescence Resonance Energy Transfer - methods</subject><subject>Humans</subject><subject>Neoplasms - diagnosis</subject><subject>Neoplasms - drug therapy</subject><issn>1078-0432</issn><issn>1557-3265</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2010</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo9kE9PwzAMxSMEYmPwEUC5ceqImz9tjmhigDQJCe0eZakzFXXNSFqkfXvabXDys_WeLf8IuQc2B5DlE7CizJjg-Xyx-MyAZcA5vyBTkLLIeK7k5aD_PBNyk9IXYyCAiWsyyZkqmBbllPhl04eIyWHrkA4itHZU2GLcHmgXbZs8RrqpQ8I2hZioD5G60RRphR26rg4ttW1F8cc2vT22wdMq9luK3tfOusMtufK2SXh3rjOyXr6sF2_Z6uP1ffG8ypzIocs488KCclwpxcELQFnJArUHteF5LjlDXwqlNfJKa8aYLEsOFWpdKKkqPiOPp7X7GL57TJ3Z1cNrTWNbDH0yhdAMtM5hcMqT08WQUkRv9rHe2XgwwMwI2IzwzAjPDICP0wHwkHs4X-g3O6z-U39E-S8U9Hcl</recordid><startdate>20100801</startdate><enddate>20100801</enddate><creator>Lu, Shaoying</creator><creator>Wang, Yingxiao</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20100801</creationdate><title>Fluorescence resonance energy transfer biosensors for cancer detection and evaluation of drug efficacy</title><author>Lu, Shaoying ; Wang, Yingxiao</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c421t-30f4a16c366631f41e5d57e9f16b322530ef84699e3d9900058831de997656d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2010</creationdate><topic>Animals</topic><topic>Biomarkers, Tumor - analysis</topic><topic>Biosensing Techniques - methods</topic><topic>Drug Resistance, Neoplasm</topic><topic>Fluorescence Resonance Energy Transfer - methods</topic><topic>Humans</topic><topic>Neoplasms - diagnosis</topic><topic>Neoplasms - drug therapy</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Lu, Shaoying</creatorcontrib><creatorcontrib>Wang, Yingxiao</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Clinical cancer research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Lu, Shaoying</au><au>Wang, Yingxiao</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Fluorescence resonance energy transfer biosensors for cancer detection and evaluation of drug efficacy</atitle><jtitle>Clinical cancer research</jtitle><addtitle>Clin Cancer Res</addtitle><date>2010-08-01</date><risdate>2010</risdate><volume>16</volume><issue>15</issue><spage>3822</spage><epage>3824</epage><pages>3822-3824</pages><issn>1078-0432</issn><eissn>1557-3265</eissn><abstract>A sensitive and specific fluorescence resonance energy transfer (FRET) biosensor was developed by Mizutani and colleagues and applied to detect the activity of BCR-ABL kinase in live cells. 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| fulltext | fulltext |
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| ispartof | Clinical cancer research, 2010-08, Vol.16 (15), p.3822-3824 |
| issn | 1078-0432 1557-3265 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_749019921 |
| source | MEDLINE; American Association for Cancer Research; EZB-FREE-00999 freely available EZB journals; Alma/SFX Local Collection |
| subjects | Animals Biomarkers, Tumor - analysis Biosensing Techniques - methods Drug Resistance, Neoplasm Fluorescence Resonance Energy Transfer - methods Humans Neoplasms - diagnosis Neoplasms - drug therapy |
| title | Fluorescence resonance energy transfer biosensors for cancer detection and evaluation of drug efficacy |
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