Fluorescence resonance energy transfer biosensors for cancer detection and evaluation of drug efficacy

A sensitive and specific fluorescence resonance energy transfer (FRET) biosensor was developed by Mizutani and colleagues and applied to detect the activity of BCR-ABL kinase in live cells. This biosensor allowed the detection of cancerous and drug-resistant cells, and the evaluation of kinase inhib...

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Veröffentlicht in:	Clinical cancer research 2010-08, Vol.16 (15), p.3822-3824
Hauptverfasser:	Lu, Shaoying, Wang, Yingxiao
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biomarkers, Tumor - analysis Biosensing Techniques - methods Drug Resistance, Neoplasm Fluorescence Resonance Energy Transfer - methods Humans Neoplasms - diagnosis Neoplasms - drug therapy
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Beschreibung
Zusammenfassung:	A sensitive and specific fluorescence resonance energy transfer (FRET) biosensor was developed by Mizutani and colleagues and applied to detect the activity of BCR-ABL kinase in live cells. This biosensor allowed the detection of cancerous and drug-resistant cells, and the evaluation of kinase inhibitor efficacy. Future biosensor development and imaging can increasingly contribute to cancer diagnosis and therapeutics.
ISSN:	1078-0432 1557-3265
DOI:	10.1158/1078-0432.CCR-10-1333