CIIA is a Novel Regulator of Detachment-Induced Cell Death

Detachment-induced cell death, or anoikis, is a type of apoptosis that occurs when epithelial cells lose their attachment to the extracellular matrix. Anoikis serves as a physiologic barrier to metastasis. Deviation from the tightly regulated mechanism of detachment-induced cell death might result i...

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Veröffentlicht in:	Cancer research (Chicago, Ill.) Ill.), 2010-08, Vol.70 (15), p.6352-6358
Hauptverfasser:	KWANG JE KIM, YU, Je-Wook, HYUN SUB HWANG, CHOI, Eui-Ju
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Anoikis - physiology Antineoplastic agents Apoptosis Regulatory Proteins - biosynthesis Apoptosis Regulatory Proteins - genetics Apoptosis Regulatory Proteins - physiology Biological and medical sciences Caspase 9 - metabolism Cell Adhesion - physiology Cell Growth Processes - physiology Cell Line Cell Line, Tumor Colonic Neoplasms - genetics Colonic Neoplasms - metabolism Colonic Neoplasms - pathology Dogs Enzyme Activation Gene Knockdown Techniques Humans Medical sciences Pharmacology. Drug treatments Transfection Tumors Up-Regulation
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Zusammenfassung:	Detachment-induced cell death, or anoikis, is a type of apoptosis that occurs when epithelial cells lose their attachment to the extracellular matrix. Anoikis serves as a physiologic barrier to metastasis. Deviation from the tightly regulated mechanism of detachment-induced cell death might result in progression to metastatic cancer. Here, we investigated the function of CIIA in the regulation of anoikis. CIIA protein was upregulated in colon cancer tissue samples. Knockdown of CIIA in metastatic colorectal carcinoma SW620 and KM12SM cells promoted detachment-induced cell death through the regulation of caspase activation. Knockdown of CIIA also inhibited anchorage-independent growth in soft agar and colony formation after suspension stress. These observations suggest that CIIA is a novel negative regulator of anoikis.
ISSN:	0008-5472 1538-7445
DOI:	10.1158/0008-5472.CAN-09-4394