A surgical technique of spinal cord cell transplantation in amyotrophic lateral sclerosis

We report an original method for implanting bone marrow stem cells within the spinal cord parenchyma. This method was used for the experimental treatment of patients diagnosed with amyotrophic lateral sclerosis. The methodology is reproducible and devoid of major complications even in patients showi...

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Veröffentlicht in:	Journal of neuroscience methods 2010-08, Vol.191 (2), p.255-257
Hauptverfasser:	Blanquer, Miguel, Pérez-Espejo, Miguel Angel, Martínez-Lage, Juan F., Iniesta, Francisca, Martinez, Salvador, Moraleda, Jose M.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Amyotrophic lateral sclerosis Amyotrophic Lateral Sclerosis - pathology Amyotrophic Lateral Sclerosis - physiopathology Amyotrophic Lateral Sclerosis - surgery Bone Marrow Transplantation - methods Bone Marrow Transplantation - pathology Cell therapy Cell- and Tissue-Based Therapy - methods Female Humans Male Middle Aged Nerve Regeneration - physiology Neurosurgical Procedures - methods Postoperative Complications - pathology Postoperative Complications - physiopathology Postoperative Complications - prevention & control Recovery of Function - physiology Spinal cord Spinal Cord - pathology Spinal Cord - physiopathology Spinal Cord - surgery Stem Cell Transplantation - methods Stereotaxic Techniques - instrumentation Treatment Outcome
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Beschreibung
Zusammenfassung:	We report an original method for implanting bone marrow stem cells within the spinal cord parenchyma. This method was used for the experimental treatment of patients diagnosed with amyotrophic lateral sclerosis. The methodology is reproducible and devoid of major complications even in patients showing significant spinal atrophy. Therefore, this report describes a surgical procedure that could be used in other experimental treatments involving the intraspinal delivery of stem cells.
ISSN:	0165-0270 1872-678X
DOI:	10.1016/j.jneumeth.2010.06.014