Reversing Cachexia
Muscle atrophy (cachexia) in cancer patients is a life-threatening condition for which therapeutic options are limited. Zhou et al. (2010) now identify a new target for treating cachexia, the activin type-2 receptor (ActRIIB). In several mouse models of cachexia, the authors reversed wasting of skel...
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| Veröffentlicht in: | Cell 2010-08, Vol.142 (4), p.511-512 |
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| Format: | Artikel |
| Sprache: | eng |
| Online-Zugang: | Volltext |
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| Zusammenfassung: | Muscle atrophy (cachexia) in cancer patients is a life-threatening condition for which therapeutic options are limited.
Zhou et al. (2010) now identify a new target for treating cachexia, the activin type-2 receptor (ActRIIB). In several mouse models of cachexia, the authors reversed wasting of skeletal and cardiac muscle and increased life span by blocking ActRIIB with a decoy receptor. |
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| ISSN: | 0092-8674 1097-4172 |
| DOI: | 10.1016/j.cell.2010.08.004 |