Polyelectrolyte Stabilized Drug Nanoparticles via Flash Nanoprecipitation: A Model Study With β-Carotene

Polyelectrolyte protected β-carotene nanoparticles (nanosuspensions) with average diameter of 80wt%, was achieved by using either PEI or chitosan. X-ray diffraction (XRD) patterns showed that β-carotene nanoparticles were amorphous. These findings open the way for utilization of FNP for preparation...

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Veröffentlicht in:	Journal of pharmaceutical sciences 2010-10, Vol.99 (10), p.4295-4306
Hauptverfasser:	Zhu, Zhengxi, Margulis-Goshen, Katrin, Magdassi, Shlomo, Talmon, Yeshayahu, Macosko, Christopher W.
Format:	Artikel
Sprache:	eng
Schlagworte:	beta Carotene - chemistry beta Carotene - pharmacokinetics biodegradable polymers Biological and medical sciences Biological Availability Electrolytes - chemistry formulation General pharmacology Hydrogen-Ion Concentration light-scattering Medical sciences Microscopy, Electron, Scanning Microscopy, Electron, Transmission mixing Molecular Weight Nanoparticles nanosuspensions Pharmaceutical Preparations - chemistry Pharmaceutical technology. Pharmaceutical industry Pharmacology. Drug treatments polyelectrolytes polymeric drug delivery systems stabilization supersaturation X-Ray Diffraction
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Zusammenfassung:	Polyelectrolyte protected β-carotene nanoparticles (nanosuspensions) with average diameter of 80wt%, was achieved by using either PEI or chitosan. X-ray diffraction (XRD) patterns showed that β-carotene nanoparticles were amorphous. These findings open the way for utilization of FNP for preparation of nanoparticles with enhanced bioavailability for highly water insoluble drugs.
ISSN:	0022-3549 1520-6017
DOI:	10.1002/jps.22090