Zinc Chloride Enhanced Arylations of Secondary Benzyl Trifluoroacetates in the Presence of β-Hydrogen Atoms

Zinc Chloride Enhanced Arylations of Secondary Benzyl Trifluoroacetates in the Presence of β-Hydrogen Atoms

Zinc or swim: Arylation of benzyl trifluoroacetates with arylzinc reagents in the presence of β‐hydrogen atoms were realized under mild conditions. Both electron‐rich and electron‐deficient arene substrates were successfully arylated. This arylation method could offer a very versatile synthetic rout...

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Veröffentlicht in:Angewandte Chemie (International ed.) 2010-08, Vol.49 (36), p.6387-6390
Hauptverfasser: Duan, Hui, Meng, Lingkui, Bao, Denghui, Zhang, Heng, Li, Yao, Lei, Aiwen
Format: Artikel
Sprache:eng
Schlagworte:
arylation
cross-coupling
CC coupling
diarylalkanes
zinc
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Zusammenfassung:Zinc or swim: Arylation of benzyl trifluoroacetates with arylzinc reagents in the presence of β‐hydrogen atoms were realized under mild conditions. Both electron‐rich and electron‐deficient arene substrates were successfully arylated. This arylation method could offer a very versatile synthetic route to access a series of diversity‐oriented diarylalkane motifs. TFA = trifluoroacetyl.
ISSN:1433-7851
1521-3773
DOI:10.1002/anie.201002116