Prognostic Significance of Age in the Radical Treatment of Oesophageal Cancer with Surgery or Chemoradiotherapy: a Prospective Observational Cohort Study

Abstract Aims To compare the outcomes of stage-directed surgical therapy and chemoradiotherapy (CRT) for oesophageal cancer and to determine if a significant age–treatment interaction exists to guide therapy. Materials and methods Five hundred and eight consecutive patients with oesophageal cancer s...

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Veröffentlicht in:	Clinical oncology (Royal College of Radiologists (Great Britain)) 2010-09, Vol.22 (7), p.578-585
Hauptverfasser:	Davies, Ll, Lewis, W.G, Arnold, D.T, Escofet, X, Blackshaw, G, Gwynne, S, Evans, M, Roberts, S.A, Appadurai, I, Crosby, T.D
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenocarcinoma - mortality Adenocarcinoma - pathology Adenocarcinoma - therapy Adult Age Factors Aged Aged, 80 and over Antineoplastic Combined Chemotherapy Protocols - therapeutic use Carcinoma, Squamous Cell - mortality Carcinoma, Squamous Cell - pathology Carcinoma, Squamous Cell - therapy Cisplatin - administration & dosage Cohort Studies Combined Modality Therapy Epirubicin - administration & dosage Esophageal Neoplasms - mortality Esophageal Neoplasms - pathology Esophageal Neoplasms - therapy Esophagectomy Female Fluorouracil - administration & dosage Hematology, Oncology and Palliative Medicine Humans Male Middle Aged Neoadjuvant Therapy oesophageal cancer operative prognosis Prospective Studies Radiology Radiotherapy Dosage surgical procedures Survival Rate Treatment Outcome
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Zusammenfassung:	Abstract Aims To compare the outcomes of stage-directed surgical therapy and chemoradiotherapy (CRT) for oesophageal cancer and to determine if a significant age–treatment interaction exists to guide therapy. Materials and methods Five hundred and eight consecutive patients with oesophageal cancer suitable for radical treatment based on radiological stage and performance status were studied (275 surgery; 93 surgery alone, 131 neoadjuvant chemotherapy, 51 neoadjuvant CRT and 233 definitive CRT). The primary measure of outcome was survival. Results Thirty-day mortality rates and 2-year survival after surgery and CRT in patients
ISSN:	0936-6555 1433-2981
DOI:	10.1016/j.clon.2010.05.023