Biosynthesis of elastin by an endothelial cell culture

An established endothelial cell culture line synthesizes and secretes into the medium a soluble protein of molecular weight approximately 75, 000 that has other properties (e.g., hydroxyproline and valylproline dipeptide contents and solubility in propanol-butanol) identifying it as elastin. This pr...

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Veröffentlicht in:Biochemical and biophysical research communications 1979-10, Vol.90 (4), p.1393-1399
Hauptverfasser: Carnes, W.H., Abraham, P.A., Buonassisi, V.
Format: Artikel
Sprache:eng
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Zusammenfassung:An established endothelial cell culture line synthesizes and secretes into the medium a soluble protein of molecular weight approximately 75, 000 that has other properties (e.g., hydroxyproline and valylproline dipeptide contents and solubility in propanol-butanol) identifying it as elastin. This protein is extractable from the washed cell layer. It is found in the medium in lower concentration together with characteristic lower molecular weight degradation products. No insoluble elastin could be detected.
ISSN:0006-291X
1090-2104
DOI:10.1016/0006-291X(79)91190-2