Placental Amino Acid Transport and Placental Leptin Resistance in Pregnancies Complicated by Maternal Obesity

Placental Amino Acid Transport and Placental Leptin Resistance in Pregnancies Complicated by Maternal Obesity

Abstract Hypothesis and study objectives We hypothesized that maternal obesity is associated with increased placental amino acid transport and hyperleptinemia. Our objectives were to study placental amino acid transport and the effect of leptin on placental amino acid transport in vitro in the setti...

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Veröffentlicht in:Placenta (Eastbourne) 2010-08, Vol.31 (8), p.718-724
Hauptverfasser: Farley, D.M, Choi, J, Dudley, D.J, Li, C, Jenkins, S.L, Myatt, L, Nathanielsz, P.W
Format: Artikel
Sprache:eng
Schlagworte:
Amino Acid Transport System A - metabolism
Amino acid transporter
Body Mass Index
Female
Humans
Immunohistochemistry
Infant, Newborn
Insulin - blood
Internal Medicine
Leptin
Leptin - blood
Obesity
Obesity - metabolism
Obstetrics and Gynecology
Placenta - metabolism
Placental dysfunction
Pregnancy
Pregnancy Complications - metabolism
SNAT
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Zusammenfassung:Abstract Hypothesis and study objectives We hypothesized that maternal obesity is associated with increased placental amino acid transport and hyperleptinemia. Our objectives were to study placental amino acid transport and the effect of leptin on placental amino acid transport in vitro in the setting of maternal obesity. Materials and methods Seven lean, BMI at entry 22.4, and seven obese, BMI at entry 31.5 ( p  
ISSN:0143-4004
1532-3102
DOI:10.1016/j.placenta.2010.06.006