Comparison of the allergic and nonallergic CD4+ T-cell responses to the major dog allergen Can f 1

[...]more recent studies have not been able to corroborate these findings convincingly, challenging the dominant role of Treg cells in the healthy immune response against respiratory allergens.3,6-8 In the current study, we aimed to dissect the factors associated with an allergic or nonallergic CD4+ T-cell response to the major dog allergen, Can f 1. No effect on the proliferative responses to Can f 1 (Fig 1, D) or streptokinase (Fig E1) was observed in the subject groups either with or without allergy. [...]only low levels of soluble IL-10 could be detected in the supernatants of either undepleted or CD25-depleted Can f 1-stimulated cultures, and these levels did not differ between subjects with and without allergy (data not shown).