Synthesis and bioassay of aminosulfonyl-1,3,4-oxadiazoles and their interconversion to 1,3,4-thiadiazoles

A new class of oxadiazoles is prepared by treating aminosulfonylacetic acids with different carboxylic acid hydrazides. Interconversion of oxadiazoles to thiadiazoles is carried out with thiourea. The compounds are screened for antimicrobial and antioxidant activities. [Display omitted]

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Bibliographische Detailangaben
Veröffentlicht in:	European journal of medicinal chemistry 2010-09, Vol.45 (9), p.4246-4251
Hauptverfasser:	Padmavathi, V., Reddy, S. Nagi, Reddy, G. Dinneswara, Padmaja, A.
Format:	Artikel
Sprache:	eng
Schlagworte:	1,3,4-oxadiazole 1,3,4-thiadiazole Anti-Infective Agents - chemical synthesis Anti-Infective Agents - chemistry Anti-Infective Agents - pharmacology Antibiotics. Antiinfectious agents. Antiparasitic agents Antimicrobial activity Antioxidant activity Antioxidants - chemical synthesis Antioxidants - chemistry Antioxidants - pharmacology Bacteria - drug effects Biological and medical sciences Biphenyl Compounds - chemistry General aspects Medical sciences Microbial Sensitivity Tests Nitric Oxide - chemistry Oxadiazoles - chemical synthesis Oxadiazoles - chemistry Oxadiazoles - pharmacology Pharmacology. Drug treatments Phosphorus oxychloride Picrates - chemistry Thiadiazoles - chemistry Thiourea
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Beschreibung
Zusammenfassung:	A new class of oxadiazoles is prepared by treating aminosulfonylacetic acids with different carboxylic acid hydrazides. Interconversion of oxadiazoles to thiadiazoles is carried out with thiourea. The compounds are screened for antimicrobial and antioxidant activities. [Display omitted]
ISSN:	0223-5234 1768-3254
DOI:	10.1016/j.ejmech.2010.06.022